Most medicines sold today are produced biotechnologically. A new cleaning method developed at the Austrian Centre of Industrial Biotechnology (acib) combines five purification steps and extremely facilitates the workup process. These microparticles technology is already used at Boehringer Ingelheim.
Researchers at The University of Akron are again spinning inspiration from spider silk - this time to create more efficient and stronger commercial and biomedical adhesives that could, for example, potentially attach tendons to bones or bind fractures.
Molecular 'fingerprint' for tissue taken from first isotope-enriched mouse has huge potential for scientific breakthroughs, as well as improved medical implants. Earliest research based on data has already revealed that a molecule thought to exist for repairing DNA may also in fact trigger bone formation.
Comparing the antibodies of sharks, which are very old from an evolutionary perspective, with those of humans, a team of researchers discovered stabilizing mechanisms that can also be applied to optimize custom-tailored antibodies in humans.
The mechanical properties of natural joints are considered unrivalled. Cartilage is coated with a special polymer layer allowing joints to move virtually friction-free, even under high pressure. Scientists have developed a new process that technologically imitates biological lubrication and even improves it using two different types of polymers.
The final step in the production of a biotech medicine is finishing with the correct sugar structure. This step is essential for the efficacy of the medicine, but it also makes the production process very complex and expensive. Now, researchers have developed a technology that shortens the sugar structures whilst retaining the therapeutic efficiency. This technology has the potential to make the production of biotech medicines significantly simpler and cheaper.
Researchers have completed a 3-D map of an enzyme called Proline utilization A (PutA). PutA facilitates metabolism by adding oxygen to molecules. Mapping this enzyme will give researchers a better understanding of its function, which could help drug manufacturers create more effective drugs.
Chemists have figured out how to control multiple bacterial behaviors - potentially good news for the treatment of infectious diseases and other bacteria-associated issues, without causing drug resistance.
Researchers use new techniques to document how cells can conceal growth, then suddenly swell like raisins into grapes; study is a 'paradigm shift' in understanding osmotic shock that may lead to new strategies for fighting bacterial disease
Scientists have merged stem cell and 'organ-on-a-chip' technologies to grow, for the first time, functioning human heart tissue carrying an inherited cardiovascular disease. The research appears to be a big step forward for personalized medicine, as it is working proof that a chunk of tissue containing a patient's specific genetic disorder can be replicated in the laboratory.