Sites where DNA is damaged may cause a molecule that slides along the DNA strand to scan for damage to slow on its patrol, delaying it long enough to recognize and initiate repair. The finding suggests that the delay itself may be the key that allows the protein molecule to find its target, according to the researchers.
Currently, doctors have to throw away more than 80 percent of donated tissue used for joint replacements because the tissue does not survive long enough to be transplanted. Now, researchers have developed a new technology that more than doubles the life of the tissue. This new technology was able to preserve tissue quality at the required level in all of the donated tissues studied, the researchers found.
These new DNA probes can potentially be used to develop a biosensor array for lanthanide and other metal detection. These DNA molecules have catalytic activity (known as DNAzymes) and studies indicate that lanthanide-dependent DNAzymes may have different properties from existing examples.
Scientists have shed light on how naturally occurring mutations can be introduced into our DNA. The study, which focuses on how DNA replicates every time a cell divides, helps to make clear previously unexplained patterns in how our DNA changes over time. It also provides new insight into how the human genome has been shaped throughout evolution.
Defective cilia can lead to a host of diseases and conditions in the human body - from rare, inherited bone malformations to blindness, male infertility, kidney disease and obesity. A new study from University of Georgia cellular biologists shows the mechanism behind tubulin transport and its assembly into cilia, including the first video imagery of the process.
To survive and fulfill their biological functions, cells need to take in material from their environment. In this process, proteins within the cell pull inward on its membrane, forming a pit that eventually encapsulates the material in a bubble called a vesicle. Researchers have now revealed a relationship that governs this process, known as endocytosis.
Scientists have developed a novel method for studying processes in the living brain, enabling them to observe how human stem cells transplanted into the cerebral cortex of mice develop into mature functional nerve cells.
Scientists from Yale have devised a way to ensure genetically modified organisms (GMOs) can be safely confined in the environment, overcoming a major obstacle to widespread use of GMOs in agriculture, energy production, waste management, and medicine.
A new computational approach allows to account for confounding factors and hidden biological processes in the analysis of single-cell RNA sequence data. Using this method, individual subpopulations and cell types can be identified within heterogeneous cell populations and can be determined more precisely.
Striving to unravel and comprehend DNA's biological significance, scientists have created a new computational method that can identify positions in the human genome that play a role in the proper functioning of cells.