Scientists have developed artificial blood vessels that are not susceptible to blood clot formation. The achievement was made possible by a new generation of drug-containing coating applied to the inner surface of the vessel.
The ability to visualize and characterize the composition of a tumour in detail during its development can provide valuable insights in order to target appropriate therapeutics. Researchers now have visualized and quantified the growth and composition of breast tumours over time in a living animal.
Researchers have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell. The engineered ribosome may enable the production of new drugs and next-generation biomaterials and lead to a better understanding of how ribosomes function.
A new technology will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as stem cell differentiation, inflammation and cancer.
Researchers have revealed the mechanism of action of the 'back brace' proteins that stabilize single strands, protect them and prevent them from folding back into a double-helix structure that can inhibit subsequent DNA processing.
Scientists have discovered the first fully synthetic substrate with potential to grow billions of stem cells. The research could forge the way for the creation of 'stem cell factories' - the mass production of human embryonic (pluripotent) stem cells.
Chemists have developed photoresponsive derivatives of an antimitotic drug, which permit light-dependent control of cell division. The new agents could provide the basis for precisely targeted tumor therapies, free of side-effects.