Using human pluripotent stem cells and DNA-cutting protein from meningitis bacteria, researchers from the Morgridge Institute for Research and Northwestern University have created an efficient way to target and repair defective genes.
Scientists have discovered an efficient process for hydrogen biocatalysis. They developed semi-synthetic hydrogenases, hydrogen-generating enzymes, by adding the protein's biological precursor to a chemically synthesized inactive iron complex. From these two components, the biological catalyst formed spontaneously in a test tube.
A scientific breakthrough by researchers at the University of Kent has revealed how vitamin B12/antipernicious anaemia factor is made - a challenge often referred to as 'the Mount Everest of biosynthetic problems'.
The method combines two high-tech laboratory techniques and allows the researchers to precisely poke holes on the surface of a single cell with a high-powered femtosecond laser and then gently tug a piece of DNA through it using optical tweezers, which draw on the electromagnetic field of another laser.
By borrowing a tool from bacteria that infect plants, scientists have developed a new approach to eliminate mutated DNA inside mitochondria - the energy factories within cells. Doctors might someday use the approach to treat a variety of mitochondrial diseases, including the degenerative eye disease Leber hereditary optic neuropathy.
A new study finds that RNA editing is not only regulated by sequences and structures near the editing sites but also by ones found much farther away. One newly discovered structure gives an editing enzyme an alternate docking site. The other appears to throttle competing splicing activity.
Scientists have developed a model that makes predictions from which differentiated cells - for instance skin cells - can be very efficiently changed into completely different cell types - such as nerve cells, for example. This can be done entirely without stem cells.
Chemical flasks and inconvenient chemostats for cultivation of bacteria are likely soon to be discarded. Researchers from the Institute of Physical Chemistry of the Polish Academy of Sciences in Warsaw were first to construct a microfluidic system allowing for merging, transporting and splitting of microdroplets.