In a novel use of gene knockout technology, researchers tested the same gene inserted into 90 different locations in a yeast chromosome - and discovered that while the inserted gene never altered its surrounding chromatin landscape, differences in that immediate landscape measurably affected gene activity.
Advances in bio-technologies and computer software have helped make genome sequencing much more common than in the past. But still in question are both the accuracy of different sequencing methods and the best ways to evaluate these efforts. Now, computer scientists have devised a tool to better measure the validity of genome sequencing.
How can bacteria protect themselves from lethal infection by viral parasites? One extreme way is for individual cells to commit suicide when infected, thereby preventing or limiting viral replication and protecting the rest of the bacterial population from subsequent infections.
Scientists have believed that microscopic organisms in the gut, microbiota, might play a crucial role in gaining weight but were never able to prove it. Groundbreaking research by a Chinese scientist has revealed a precise link.
Growing new blood vessels in the lab is a tough challenge, but a Johns Hopkins engineering team has solved a major stumbling block: how to prod stem cells to become two different types of tissue that are needed to build tiny networks of veins and arteries.
An international consortium with representatives from most of the world's major cotton-producing countries, led by Regents Professor Andrew Paterson of the University of Georgia and including Candace Haigler, a North Carolina State University professor of crop science and plant biology, has described the first 'gold-standard' genome sequence for cotton.