Engineers have modified the cotton candy machine to create complex microfluidic networks that mimic the capillary system in living tissue and have demonstrated that these networks can keep cells alive and functioning in an artificial three-dimensional matrix.
Researchers have engineered a new synthetic biopathway that can more efficiently and cost-effectively turn agricultural waste, like corn stover and orange peels, into a variety of useful products ranging from spandex to chicken feed.
Stem cell-derived heart muscle cells may fail to effectively replace damaged cardiac tissue because they don't contract strongly enough, according to a new study. This study may help explain why stem cell-based therapies have so far shown limited benefits for heart attack patients in clinical trials.
A microreactor developed as part of a collaborative research project enables cultured liver cells to be used as test samples. Unlike animal testing, this novel method enables the assessment of potentially toxic substances on tissue in real time.
Researchers have developed a range of synthetic biomimetic compounds to replace the relatively expensive natural NADH and NADPH coenzymes in enzymatic conversions of industrial relevance. They show that some of the compounds even outperform their natural counterparts.
Researchers improved on existing technologies to create a modified single-stranded DNA molecule called aptamer. DNA aptamers are ideal for pharmaceutical applications because they can specifically bind to any molecular target in the body such as proteins, viruses, bacteria and cells.
Researchers have developed a new biodegradable material with built-in vitamin A, which has been shown to reduce scarring in blood vessels. This soft elastic material can be used to treat injured vessels or be used to make medical devices, such as stents and prosthetic vascular grafts, to give them intrinsic healing properties.
Engineered liver tissue could have a range of important uses, from transplants in patients suffering from the organ?s failure to pharmaceutical testing. Now scientists report the development of such a tissue, which closely mimics the liver?s complicated microstructure and function more effectively than existing models.
Scientists have discovered a molecule that interrupts biochemical signals essential for the survival of tumor cells called Wnt-addicted cancer stem cells. The discovery is the product of an approach known as 'rational drug design', targeting specific molecules based on a thorough understanding of the biology of a disease and the biochemical signals that support it.