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A new self-assembly process allows the recognition of specific DNA sequences

Researchers have introduced a new approach for achieving a highly selective, recognition of designed nine DNA base pairs. The strategy involves the nickel-promoted assembly of a peptide derived from a transcription factor, and a small molecule equipped with a metal-binding unit that acts as heterodimerizing staple.

Posted: Oct 16th, 2014

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Easy recipe to make bone and cartilage

The repair of large bone defects and damaged cartilage remains a significant clinical challenge, with current strategies unable to reliably generate the cells that make bone and cartilage. Now, researchers are able to produce such cells by exposing embryonic stem cells to a combination of small molecules, mimicking normal development. This strategy is easily scalable, offering great potential in bone and cartilage regenerative medicine.

Posted: Oct 7th, 2014

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Sorting stem cells

New technique allows scientists to identify populations of rare stem cells in bone marrow.

Posted: Oct 6th, 2014

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A new way to extract bone-making cells from fat tissue

By sorting human fat tissue cells by their expression of a certain gene, scientists were able to retrieve a high yield of cells that showed an especially strong propensity to make bone tissue. With more refinement, the method could improve the ability of surgeons to speed bone healing.

Posted: Oct 6th, 2014

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Scientists develop barcoding tool for stem cells

A seven-year-project to develop a barcoding and tracking system for tissue stem cells has revealed previously unrecognized features of normal blood production: new data suggests, surprisingly, that the billions of blood cells that we produce each day are made not by blood stem cells, but rather their less pluripotent descendants, called progenitor cells.

Posted: Oct 5th, 2014

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'Programmable' antibiotic harnesses an enzyme to attack drug-resistant microbes

Conventional antibiotics are indiscriminate about what they kill, a trait that can lead to complications for patients and can contribute to the growing problems of antibiotic resistance. But a a 'programmable' antibiotic being developed at Rockefeller would selectively target only the bad bugs, particularly those harboring antibiotic resistance genes, and leave beneficial microbes alone.

Posted: Oct 5th, 2014

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RCas9: A programmable RNA editing tool

A powerful scientific tool for editing the DNA instructions in a genome can now also be applied to RNA as researchers have demonstrated a means by which the CRISPR/Cas9 protein complex can be programmed to recognize and cleave RNA at sequence-specific target sites.

Posted: Oct 3rd, 2014

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