Scientists at The Scripps Research Institute have invented small-molecule folding probes that enable them to quantify functional, normally folded and disease-associated misfolded conformations (shapes) of a protein-of-interest in cells under different conditions.
Researchers have developed a new method that allows scientists to pinpoint thousands of mRNAs and other types of RNAs at once in intact cells - all while determining the sequence of letters, or bases, that identify them and reveal what they do.
At Deutsches Elektronen-Synchrotron's PETRA III research light source, scientists have carried out the first studies of living biological cells using high-energy X-rays. The new method for the first time enables us to investigate the internal structures of living cells in their natural environment using hard X-rays.
Chemists from Radboud University Nijmegen and the Foundation for Fundamental Research on Matter (FOM) have succeeded in producing detailed 3D structures of selected peptides - the building blocks of proteins.
Scientists have made an important breakthrough: they have discovered a way to transform skin cells into mature, fully functioning liver cells that flourish on their own, even after being transplanted into laboratory animals modified to mimic liver failure.
A new bioprinting method developed at the Wyss Institute for Biologically Inspired Engineering at Harvard University and the Harvard School of Engineering and Applied Sciences creates intricately patterned 3-D tissue constructs with multiple types of cells and tiny blood vessels. The work represents a major step toward a longstanding goal of tissue engineers: creating human tissue constructs realistic enough to test drug safety and effectiveness.