Defective cilia can lead to a host of diseases and conditions in the human body - from rare, inherited bone malformations to blindness, male infertility, kidney disease and obesity. A new study from University of Georgia cellular biologists shows the mechanism behind tubulin transport and its assembly into cilia, including the first video imagery of the process.
To survive and fulfill their biological functions, cells need to take in material from their environment. In this process, proteins within the cell pull inward on its membrane, forming a pit that eventually encapsulates the material in a bubble called a vesicle. Researchers have now revealed a relationship that governs this process, known as endocytosis.
Scientists have developed a novel method for studying processes in the living brain, enabling them to observe how human stem cells transplanted into the cerebral cortex of mice develop into mature functional nerve cells.
Scientists from Yale have devised a way to ensure genetically modified organisms (GMOs) can be safely confined in the environment, overcoming a major obstacle to widespread use of GMOs in agriculture, energy production, waste management, and medicine.
A new computational approach allows to account for confounding factors and hidden biological processes in the analysis of single-cell RNA sequence data. Using this method, individual subpopulations and cell types can be identified within heterogeneous cell populations and can be determined more precisely.
Striving to unravel and comprehend DNA's biological significance, scientists have created a new computational method that can identify positions in the human genome that play a role in the proper functioning of cells.
Scientists have devised a new strategy for selectively delivering genes into the mitochondria of plant cells by using a simple combination of cell-penetrating and mitochondria-targeting peptides. This work lays the groundwork for the rational design of peptide-based gene carriers with the potential to create a new field of 'mitochondria engineering', which could enable the creation of mitochondria-based plant cell factories for the creation of bio-polymers and bio-fuels.
Researchers have succeeded for the first time in amplifying gene samples containing DNA adducts while retaining references to these adducts. This type of amplification is a prerequisite for the majority of technologies used by researchers to determine a gene's DNA sequence.