Exploring the fundamental mechanism by which a cell-surface receptor transmits its signal, researchers have established proof of concept for an entirely new approach to drug design. They report that a class of synthetic molecules known as diabodies can, from outside the cell, latch onto a target receptor and manipulate it in such a manner as to induce distinct and varying effects within cells and tissues.
A research collaboration develops a new open access tool called PolyMaker that will support the selection of beneficial traits for future crop breeding programmes. The new software enables automated primer design for multiple genome species, significantly reducing the time of multiple genome analysis.
Researchers have managed to bond positively charged phosphorus atoms with positively charged hydrogen ones. Their insight may prove pivotal to understanding how biologically important molecules such as DNA and proteins form properly.
Scientists have created a 3-D model of a complex protein machine, ORC, which helps prepare DNA to be duplicated. But the new information has uncovered another mystery: ORC's structure reveals that it is not always 'on' as was previously thought, and no one knows how it turns on and off.
Researchers have developed a new injectable polymer that strengthens blood clots, called PolySTAT. Administered in a simple shot, the polymer finds any unseen or internal injuries and starts working immediately.
The new system - called BASIC - is a major advance for the field of synthetic biology, which designs and builds organisms able to make useful products such as medicines, energy, food, materials and chemicals.
Researchers examined the evolution origins of the D1 protein in cyanobacteria, which forms the heart of Photosystem II, the oxygen-evolving machine of photosynthesis. The research team selected all known D1 sequences from cyanobacteria and also representatives from algae and plants to compare the protein sequence variation.
Researchers used advanced proteomic techniques to identify 1,750 unique proteins in shoots of switchgrass, a native prairie grass viewed as one of the most promising of all the plants that could be used to produce advanced biofuels.
Researchers have successfully corrected a genetic error in stem cells from patients with sickle cell disease, and then used those cells to grow mature red blood cells. The study represents an important step toward more effectively treating certain patients with sickle cell disease who need frequent blood transfusions and currently have few options.
Researchers have created a 'heart-on-a-chip' that effectively uses human cardiac muscle cells derived from adult stem cells to model how a human heart reacts to cardiovascular medications. The system could one day replace animal models to screen for the safety and efficacy of new drugs.