Researchers at the Polytechnic Institute of New York University and the NYU College of Dentistry have developed a carrier in their lab that is five times more efficient in delivering DNA into cells than today's commercial delivery methods - reagent vectors. This novel complex is a peptide-polymer hybrid, assembled from two separate, less effective vectors that are used to carry DNA into cells. The study helps researchers better understand gene function.
Researchers managed to overcome remaining key limitations of RNA interference (RNAi) - a unique method to specifically shut off genes. By using an optimized design, the scientists were able to inhibit genes with greatly enhanced efficiency and accuracy.
As more reports appear of a grim 'post-antibiotic era' ushered in by the rise of drug-resistant bacteria, a new strategy for fighting infection is emerging that targets a patient's cells rather than those of the invading pathogens. The technique interferes with the way that the pathogens take over a patient's cells to cause infection.
Since the discovery of penicillin, fungi have been a nearly inexhaustible source for the discovery of new drugs. 'Crowdsourcing', the cooperation of a large number of interested nonscientists, has helped to find a new fungus from which American researchers have now isolated and characterized an unusual metabolite with interesting antitumor activity.
The Petri dish is a classical biological laboratory device, but it is no ideal living environment for many types of cells. Studies lose validity, as cell behavior on a flat plastic surface differs from that in branched lung tissue, for example. Researchers of Karlsruhe Institute of Technology have now presented a method to make three-dimensional structures attractive or repellent for certain types of cells.
Funds extend a decade of unclassified research at UCSB's Institute for Collaborative Biotechnologies in areas such as biotechnology tools, futuristic materials, energy generation and storage, systems and synthetic biology, and neuroscience.