Knowing virtually everything about how the body's cells make transitions from one state to another - for instance, precisely how particular cells develop into multi-cellular organisms - would be a major jump forward in understanding the basics of what drives biological processes.
A new study has discovered the role of a protein in bacteria that cause a wide variety of diseases, including typhoid fever, plague, meningitis and dysentery. The results may lead to new and improved antibiotics for humans and animals.
Scientists using sophisticated imaging techniques have observed a molecular protein folding process that may help medical researchers understand and treat diseases such as Alzheimer's, Lou Gehrig's and cancer.
CEA-Leti today introduced a new video lens-free imaging technique that redefines bio imaging, provides significant advantages over traditional microscopy, and opens a new range of capabilities for researchers, such as real-time monitoring of cell cultures.
A new method of maturing human heart cells that simulates the natural growth environment of heart cells while applying electrical pulses to mimic the heart rate of fetal humans has led researchers at the University of Toronto to an electrifying step forward for cardiac research.
The advance should allow deeper insights into protein function, Chase says, "because we can only get a true understanding of what that single protein does when we isolate its function." There was no tool to do this. Cover art uses a worm jigsaw puzzle to illustrate how knockdown strategies have evolved to achieve more cell-type specificity, culminating in the new approach, which can restrict knockdown to a single cell type.
Senior Brandeis research scientist Daniel Perlman has discovered a way to make phytosterol molecules from plants dispersible in beverages and foods that are consumed by humans, potentially opening the way to dramatic reductions in human cholesterol levels.
The project BASYNTHEC ('Bacterial synthetic minimal genomes for biotechnology') launched in 2010 with almost EUR 3 million in EU funding. It sought to develop a model-based approach for engineering B. subtilis and create synthetic modules for producing metabolites and proteins of interest. Ultimately, the research could lead to new antimicrobial treatments for bacterial infections.
Researchers at Arizona State University's Biodesign Institute have produced the first genome-wide investigation of cap-independent translation, identifying thousands of mRNA sequences that act as Translation Enhancing Elements (TEEs), which are RNA sequences upstream of the coding region that help recruit the ribosome to the translation start site.