Scientists discovered that living cell migration is regulated by the engagement of a force transmitter composed of vinculin and talin, two types of cytoskeletal protein. The researchers showed that force-dependent vinculin binding to talin plays a critical role in mechanically connecting the actin cytoskeleton to the extracellular substrate to contribute towards cell migration.
Deep within most tumors lie areas that remain untouched by chemotherapy and radiation. These troublesome spots lack the blood and oxygen needed for traditional therapies to work, but provide the perfect target for a new cancer treatment using bacteria that thrive in oxygen-poor conditions. Now, researchers have shown that injections of a weakened version of one such anaerobic bacteria can shrink tumors in rats, pet dogs, and a human patient.
Spider silk is light and delicate, while incredibly resilient and tear-resistant. Understanding the structure and way of construction of these threads is a challenge taken up by a research team of Kiel University.
Biophysics is a science of shapes - the shapes of molecules like DNA as they wrap and unwrap around protein cores, for instance. Researchers have unveiled a new method for observing such processes in real time.
Researchers have created a molecule that can cause cancer cells to self-destruct by ferrying sodium and chloride ions into the cancer cells. These synthetic ion transporters confirm a two-decades-old hypothesis that could point the way to new anticancer drugs while also benefitting patients with cystic fibrosis.
Numerous obstacles posed by cellular structures hinder protein movements within the cell. Researchers now have succeeded in mapping the intracellular topology by observing proteins in living cells on multiple time and length scales. By developing a new fluorescence microscopy-based technique, the researchers were able to measure how long it takes proteins to move over distances ranging from 0.2 to 3 micrometres in living cells.