Researchers bioengineered the microstructures to be the same size, shape and stiffness as adult heart muscle cells, or cardiomyocytes, with the goal of releasing biologically active peptides that act as cardioprotective agents.
Lab-on-a-chip (LOC) systems have registered tremendous progress over the past 20 years. Myriad 'chip' schemes have already emerged, ranging from the lung-on-a-chip and heart-on-a-chip to the liver-on-a-chip and kidney-on-a-chip. However, until now, an ideal embryo-on-a-chip has not yet been developed due to challenges in condensing so many life factors inside a conventional LOC.
Researchers in Japan have succeeded in inducing human embryonic stem cells to self-organize into a three-dimensional structure similar to the cerebellum, providing tantalizing clues in the quest to recreate neural structures in the laboratory.
The scientific community represented by about forty researchers and officials from research funding organisations gathered in Brussels on 23 January 2015 to present the outcomes of the European Science Foundation's (ESF) Foresight Activity on Research in Quantum Biology (FarQBio).
Sites where DNA is damaged may cause a molecule that slides along the DNA strand to scan for damage to slow on its patrol, delaying it long enough to recognize and initiate repair. The finding suggests that the delay itself may be the key that allows the protein molecule to find its target, according to the researchers.
Currently, doctors have to throw away more than 80 percent of donated tissue used for joint replacements because the tissue does not survive long enough to be transplanted. Now, researchers have developed a new technology that more than doubles the life of the tissue. This new technology was able to preserve tissue quality at the required level in all of the donated tissues studied, the researchers found.
These new DNA probes can potentially be used to develop a biosensor array for lanthanide and other metal detection. These DNA molecules have catalytic activity (known as DNAzymes) and studies indicate that lanthanide-dependent DNAzymes may have different properties from existing examples.
Scientists have shed light on how naturally occurring mutations can be introduced into our DNA. The study, which focuses on how DNA replicates every time a cell divides, helps to make clear previously unexplained patterns in how our DNA changes over time. It also provides new insight into how the human genome has been shaped throughout evolution.
Defective cilia can lead to a host of diseases and conditions in the human body - from rare, inherited bone malformations to blindness, male infertility, kidney disease and obesity. A new study from University of Georgia cellular biologists shows the mechanism behind tubulin transport and its assembly into cilia, including the first video imagery of the process.