For centuries, man has searched for miracle cures to end suffering caused by disease and injury. Many researchers believe nanotechnology applications in medicine may be mankind's first 'giant step' toward this goal. According to Freitas nanomedicine is "...(1) the comprehensive monitoring, control, construction, repair, defense, and improvement of all human biological systems, working from the molecular level, using engineered nanodevices and nanostructures; (2) the science and technology of diagnosing, treating, and preventing disease and traumatic injury, of relieving pain, and of preserving and improving human health, using molecular tools and molecular knowledge of the human body; (3) the employment of molecular machine systems to address medical problems, using molecular knowledge to maintain and improve human health at the molecular scale." Nanomedicine not only has the potential to change medical science dramatically but to open a new field of human enhancements that is poised to add a profound and complex set of ethical questions for health care professionals. For instance, there is a fine line between medical and non-medical uses of nanotechnology for diagnostic, therapeutic and preventive purposes (e.g. non-medical implants in soldiers). The question of whether nanotechnology should be used to make intentional changes in or to the body when the change is not medically necessary is just one hot topic in a long list of concerns. The good news is that these questions are being asked, but there is still much work to be done, but despite the enormous promise of nanomedicine, and the considerable funding going into the field, the research into the ethical, legal and social implications of nanomedicine is comparatively minute. As Peter Singer wrote in his 2003 tutorial Mind the gap: science and ethics in Nanotechnology: 'The science leaps ahead, the ethics lags behind.' As with nanotechnology in general, there is danger of derailing nanomedicine if the study of ethical, legal and social implications does not catch up with scientific developments.
1,300 to 1,400 grams and several thousand kilometers of about 100 billion interconnected nerve cells control every movement, thought, sensation, and emotion that comprise the human experience. Within the brain and spinal cord there are ten thousand distinct varieties of neurons, trillions of supportive cells, a few more trillion synaptic connections, a hundred known chemical regulating agents, kilometers of minuscule blood vessels, and untold mysteries of how - almost flawlessly - all these components work together. This is the amazing brain. Given the incredible complexity of the brain, it doesn't come as a big surprise that a lot of things can go wrong. The A-Z of brain disorders is a very long list. Several of these disorders (such as Parkinson and Alzheimer disease, but also schizophrenia, epilepsy, and bipolar disorder), not to mention tumors, are so severe that they require treatment of the brain. But even when there are promising pharmaceutical compounds for their treatment, more than 98% of these potential agents do not reach the drug development stage. The reason is the blood-brain barrier (BBB), a tight seal of endothelial cells lines the blood vessels in the brain and acts as a barrier to protect its cells. BBB strictly limits transport into the brain through both physical (tight junctions) and metabolic (enzymes) barriers and keeps most substances, such as chemicals and large biomolecules, out of the brain. The combined use of peptides and nanotechnology offers tremendous hope in the treatment of brain disorders by offering a way for drugs (the therapeutic kind) across the BBB.
The human eye is an amazing organ. It is small, the eyeball itself weighs only about 7 grams, and it is amazingly sensitive. The eye can detect a single photon. The eye can be quicker then a race car - the young human eye can focus from infinity to 7cm in 350 milliseconds - but slow enough to witness a snail crawling across a beach. The eye can capture objects at various different angles, such as birds flying overhead or a person walking right beside you. Because the eye is such a complex optical system, it is not surprising that the list of diseases and infections that can endanger our vision is a long one. One common age-related condition is cataract. Cataract is caused by alterations in the protein structure of the lens which result in light scattering. The lens can then no longer transmit a clear picture to the retina where it can be processed and sent through the optic nerve to the brain. By age 65, over 40% of people have a cataract. Cataract is the most common cause of blindness in the world, although it is treatable. While cataract surgery is the most successful medical procedure, the inability to control penetration of the pharmacological agents into the lens and target specific intracellular biochemical pathways has impeded the success of pharmacological treatment of cataracts. Researchers are now studying the application of nanotechnology to eye lens diseases, in particular for new methods for visualizing and targeting specific intracellular mechanisms within the eye.
The concept of nanodentistry was introduced by Freitas in 2000: "Nanodentistry will make possible the maintenance of comprehensive oral health by employing nanomaterials, biotechnology including tissue engineering, and, ultimately, dental nanorobotics." Dental nanorobots are certainly many years off but researcher are making progress already with nanotechnology in dental care applications such as composites, bonding agents, and impression materials as well as nanostructured implant materials. For those of you with hypersensitive teeth, a new nanotechnology treatment proposed by researchers in Taiwan might one day bring pain relief. Dentine hypersensitivity (dentin is the main tissue that forms the shape of the tooth; this material exists between the pulp and the enamel, and is comprised of a series of dentinal tubules stacked on top of each other) leads to pain when fluid movement in dentinal tubules (microscopic canals that run from the outside of the dentin to the nerve inside the tooth) promotes mechanical deformation of nerve endings at the pulp/dentine interface, which is transmitted as a painful sensation. Researchers have found that sensitive teeth have an increased number of dentinal tubules (35.6% compared to 9.3%) and are wider in diameter than the dentinal tubules of non sensitive dentine. The Chinese researchers have demonstrated that this tubules can be blocked with the aid of gold nanoparticles. The world's smallest gold fillings, so to speak.
Shorter-wavelength surface-emitting laser sources are important for a variety of fields including photonics, information processing and biology. Researchers in Japan were successful in developing a current-driven blue-violet photonic crystal surface-emitting laser. They developed a fabrication method, named 'air holes retained over growth', in order to construct a two-dimensional gallium nitride/air photonic crystal structure. The resulting periodic structure has a photonic crystal band-edge effect sufficient for the successful operation of a current-injection surface-emitting laser. This represents an important step in the development of laser sources - from both a scientific and engineering point of view - that could be focused to a size much less than the wavelength and be integrated two-dimensionally at such short wavelengths.
DNA, the blueprint of life, and electronics seem to be two completely different things but it appears that DNA could offer a solution to many of the hurdles that need to be overcome in further scaling down electronic circuits beyond a certain point. The reason why DNA could be useful in nanotechnology for the design of electric circuits is the fact that it actually is the best nanowire in existence - it self-assembles, it self-replicates and it can adopt various states and conformations. Not surprisingly, performing reliable experiments on a single oligo-DNA molecule is an extremely delicate task as partly contradicting research reports demonstrate: Different DNA transport experiments have shown that DNA may be insulating, semiconducting, or metallic. Among the numerous factors that could impact the results are the quality of the DNA-electrode interface, the base pair, the charge injection into the molecule, or environmental effects such as humidity or temperature. Researchers have now demonstrated a novel carbon nanotube-based nanoelectronic platform as proof of concept that single DNA molecules can be detected. This novel detection technique is based on change in electrical conductance upon selective hybridization of the complementary target DNA with the single stranded probe attached to the system. The single-stranded sequence-specific probe DNA whose ends are modified with amine is attached between two carbon nanotubes/nanowires using dielectrophoresis (DEP). This platform can be used for understanding how electrical charge moves through DNA which could help researchers understand and perhaps develop a technique for reversing the damage of DNA done by oxidation and mutation.
One of the more interesting concerns of nanotechnology is 'grey goo.' The term was invented by Eric Drexler to describe one of the dangerous issues that must be faced as nanotechnology capabilities evolve. Here's how it works. 1. Pretend that nanotechnology truly exists to the point where we can fabricate machines of arbitrary complexity using individual atoms or molecules. 2. Pretend that these machines have sufficient complexity and computational means that they can make copies of themselves using whatever happens to be lying within their reach. 3. Pretend that their fabrication systems are such that they can make a copy of themselves about once an hour. 4. Pretend that one of these machines decides to do nothing except make copies of itself.
In 1954, Richard Buckminster Fuller was granted U.S. Pat. No. 2,682,235 for geodesic domes, a method of enclosing space in architectural applications. The geodesic dome combines the structural advantages of the sphere (which encloses the most space within the least surface, and is strongest against internal pressure) with those of the tetrahedron (which encloses least space with most surface and has the greatest stiffness against external pressure). Subsequently, soccer ball shaped carbon molecules known as fullerenes or buckyballs were named for their resemblance to a geodesic sphere. But is not only certain carbon molecules where Nature uses sphere-like forms. Spheres can be found at all scales in both the inanimate and living world for the basic physical property of encapsulation. Spherical virus capsids (a capsid is the protein shell of a virus), for example, enclose space by using the geometry of the icosahedron, thus exploiting the economy of this form in terms of both surface area-to-volume ratio and genetic efficiency of subunit-based symmetric assembly. Many viruses' capsids use icosahedral symmetry to form particles ranging from 20 to 200 nanometers in size. Researchers have now begun to copy Nature's icosahedral-symmetry design principles for molecular containers, which could solve the problem of designing and synthesizing stable molecular containers having very large interior.