As an emerging science, nanotoxicology is expanding the boundaries of traditional toxicology from a testing and auxiliary science to a new discipline where toxicological knowledge of nanomaterials can be put to constructive use in therapeutics as well as the development of new and better biocompatible materials. Until now, though, no one has been able to pin-point which properties determines or influences the inherent hazards of nanoparticles. Now, scientists have developed a framework that can be applied to a suggested hazard identification approach and is aimed at identifying causality between inherent physical and chemical properties and observed adverse effects reported in the literature.
Past studies of photo-responsive proteins have generally dwelled on applications for energy-saving computer displays, light-based computing or computer memory. The general theme in the research tends to rely on the controllable and quick state change of the protein. But, the ability of the protein to actually incite a physical change in a composite macroscopic system has been largely unexplored. Harnessing this ability of the protein to incite change in a polymeric material could have broad implications in the field of biomedical and materials engineering. Getting bacteriorhodopsin to 'play ball' with other bulk materials could render those materials sensitive to a light. As a stimulus, light is often much easier to control than those typically explored by researchers such as bulk pH, temperature or electric fields.
Given past revelations of previously top secret military technology programs there is a good chance that some 'black' projects somehwere tinker with advanced nanotechnology applications. But, you keepers of military secrets, relax. This Spotlight is not a piece of investigative journalism into the world of military black projects. It is the first in a series of eight scenarios that have just been published by the Center for Responsible Nanotechnology (CRN) - and we here at Nanowerk have posted the entire nanotechnology scenario project here. CRN's scenarios depict various versions of a near-future world into which transformative manufacturing concepts may emerge. Across eight separate storylines, an international team of policy, technology, and economic specialists organized by CRN imagined in detail a range of plausible, challenging events - from pandemics to climate crises to international conflicts - to see how they might affect the development of advanced nanotechnology over the next 15 years. Please keep in mind that this and the others seven scenarios are NOT predictions but fiction. CRN intends the scenarios to provide a springboard for discussion of molecular manufacturing policies and societal responses. While each scenario can be understood individually, the real value of the process comes from the comparison of multiple scenarios. A strategic response that appears robust in one scenario may be dangerous in another; an organization, community, or polity using these scenarios to consider how to handle the emergence of molecular manufacturing should strive for responses that are viable across multiple scenarios.
Carbon nanotubes (CNTs) have shown promise as an important new class of multifunctional building blocks and innovative tools in a large variety of nanotechnology applications, ranging from nanocomposite materials through nanoelectronics to biomedical devices (e.g. gene and drug carriers). The recent rapid development in nanotechnology has renewed the pressing demand for large-scale production of CNTs for potential applications in commercial products. The number of industrial-scale facilities for the increasingly low-cost production of multi-walled carbon nanotubes (MWCNTs) continues to grow, and with that the professional and public exposure to MWCNTs is expected to increase significantly in the coming years. Owing to their unusual one-dimensional hollow nanostructure and unique physicochemical properties, CNTs are particularly useful as novel drug delivery tools and imaging agents. However, such biomedical, and many other related, applications will not be realized if there is no proper assessment of the potential hazards of CNTs to humans and other biological systems. This situation prompted a group of researchers to carry out the first genotoxicity study of nanomaterials. Although the health effects of nanomaterials have attracted considerable attention, the scientific community has thus far focused primarily on the studies of nanomaterials toxicity at the cellular level. Very little is known about the toxicity at the molecular level, or genotoxicity, of nanomaterials in mammalian cells. Researchers at the University of Dayton have assessed the DNA damage response to MWCNTs in mouse embryonic stem cells (ES). This new work emphasizes the importance of careful scrutiny of the genotoxicity of nanomaterials.
The Bronze Age technique of soldering - a process in which two or more metal items are joined together by melting and flowing a filler metal into the joint - seems to be working just fine in the nanotechnology age. Researchers in California have developed an alternative method, effectively a miniaturization of soldering, to electron beam lithography (EBL) which, so far, is the method of choice for making electrical contact to nanostructures is. Carbon nanotubes, for instance, have been soldered together by using electron beam deposited gold molecules. There is a downside to using EBL as an industrial fabrication process: commercially used dedicated e-beam writing systems are very expensive (millions of dollars per unit), the process is complex, time-consuming and not really suitable for high-volume manufacturing, and there is a risk of sample contamination build-up on the samples. Other lithography-free contacting techniques such as shadow masks have been attempted, but they have their own drawbacks and have not been widely used. The new nano-soldering technique allows to make submicron sized, Ohmic contacts to nanostructures of even single atom thickness. The technique is simple, inexpensive, rapid, and entirely avoids sample contamination.
Pipettes (from the French: little pipe) are one of those ubiquitous tools you find in every chemical, medical or biology lab. The original pipette is made of glass and it works by creating a vacuum above the liquid-holding chamber and selectively releasing this vacuum to draw up and dispense liquid. With the advance of molecular biology, researchers required pipettes that were able to confine smaller and smaller amounts of specimen, not only for probing but also for injecting drugs, DNA etc. into cells - without damaging the cells, of course. Just a few months ago, researchers at the Brookhaven National Laboratory have developed what is thought to be the world's smallest pipette: made of a carbon-coated germanium nanowire it can hold a volume of only a few zeptoliters (a billionth of a trillionth of a liter, or one thousand cubic nanometers). Although today it even is possible to process the tip of a glass pipette to have an inner diameter as small as several tens of nanometers, this involves considerable problems in terms of the processing accuracy and the operability of the pipette, particularly in terms of locating the tip. It is generally considered that probes made from carbon nanotubes (CNTs) and nanoscale carbon pipes offer an attractive alternative to glass pipettes because of their small size, high mechanical strength, and high electrical conductivity. Researchers at the University of Pennsylvania have developed a manufacturing technique for carbon nanopipettes (CNPs) that does not require cumbersome nanoassembly and is amenable to mass production.
Molecular bioelectronics is a rapidly progressing research field that is concerned with the movement of electrons and ions within living systems. This field brings together the strengths of biological reactions and biochemical interactions from nature with electronic signal detection and amplification of human electronics technology. The result will be new applications in medicine, diagnostics and therapeutics that would never be imaginable within the limitations of each separated domain. One day, bioelectronic devices could even be be directly involved in electrical communication with signal producing or controlling molecules, organelles or structures within our bodies. A more short-term goal, though, is the development of biosensors (such as enzyme-based sensors and DNA sensors) to combine the extraordinary specificity of biochemical receptors with general purpose microelectronics to develop selective probes for diagnostics, drug screening, and toxin detection. An example of recent advances in the field is the work of researchers in the U.S. who have designed an integrated nanobioelectronic system, exploiting the distinct properties of nanowires and carbon-nanotubes, for triggering reversibly and on-demand bioelectrocatalytic transformations of alcohols. Such an adaptive magneto-switchable nanobioelectronic system exploits the distinct properties of its individual nanomaterial components, can be extended to a wide range of biocatalytic systems, and offers great promise for regulating the operation of biofuel cells, bioreactors, and biosensing devices in response to specific needs.
The human body so far is the ultimate 'wet computer' - a highly efficient, biomolecule-based information processor that relies on chemical, optical and electrical signals to operate. Researchers are trying various routes to mimic some of the body's approaches to computing. Especially research related to molecular logic gates is a fast growing and very active area. Already, common logic gates, which are used in conventional silicon circuitry, can be also mimicked at the molecular level. Chemists have reported that a molecular logic gate has the potential for calculation on the nanometer scale, which is unparalleled in silicon-based devices. The general character of the concept of binary logic allows the substitution of electrical signals by chemical and optical signals, which for example opens access to a vast pool of photoactive molecules to be used for the purpose of molecular logic. Molecular logic gate structures using fluorescence changes have been studied intensively using various inputs, such as pH, metal ions, and anions. Now, South Korean scientists using solutions of fluorescent sensor molecules - and, for the first time, proteins - have developed the first soluble molecular logic gates. By using a microfluidic device, input solutions are routed into a central loop, which is filled with a fluorescent sensor solution. There the solutions mix and, in certain combinations, switch the fluorescence 'output' on or off.