Previous reports have shown that when nanoparticles enter the blood stream, the proteins that adsorb onto nanoparticles when they enter the body form a protein corona that hinders interactions between the targeting ligands on the nanoparticles and their binding partners on the cells' surface. To address this issue, scientists have developed a strategy that enables directing the formation of protein coronas on nanoparticles that are enriched in plasma proteins with natural targeting capabilities.
The complexity of the microenvironment of a biological cell is influenced by many factors, including surface topography and chemistry; matrix stiffness; mechanical stress; molecular liquid composition and other physiochemical parameters. However, most artificial biointerfaces are developed based on just a single chemical or physical factor to direct cell behaviors. The functions performed by these artificial biointerfaces are far simpler than those performed in the natural cell microenvironment. In an effort to more closely mimic a cell's natural environment, researchers have fabricated an antibody modified reduced graphene oxide platform and used it to significantly improve the efficiency for capturing circulating tumor cells.
A typical preliminary test for tuberculosis includes culturing the samples for at least 1-2 weeks in a lab, followed by examination under a fluorescence microscope. The lack of rapid, accurate, and inexpensive point-of-care tools for detecting low amounts of M. Tuberculosis is a critical bottleneck in early diagnosis and appropriate treatment. Researchers have now developed a rapid and flexible nano-biosensor for diagnosing TB in early stages using smart phones.
Skin thermal burns are a complex and major source of morbidity, mortality and healthcare expenditure. Given the range of causes, from fire associated injury to water scalding, patients often present with multiple and complex burns - wounds that often worsen and expand over the first few days do to the associated underlying inflammation and injury. To facilitate better wound healing, researchers have developed nanoparticles that can both release the potent biomolecule nitric oxide (NO) over time, as well as facilitate nitrosation, the addition of an NO group to a biological molecule, which is central many of NO's activity.
Microwave hyperthermia is one of the most important clinical thermotherapy techniques, however, it is often difficult to apply heat locally to a tumor. By bringing together experts in medicine with experts in nanotechnology, researchers aim to explore the possibilities of designing microwave sensitive agents, which focus the destructive effects of microwaves specifically onto tumor cells. Scientists have now proposed a novel approach to apply micro- and nanomaterials as microwave susceptible agents in tumor hyperthermia in vivo for the first time.
Upconversion luminesce materials are promising for widespread application ranging from optical devices to biodetection and cancer therapy, the near-infrared light excited upconversion materials are attracting much research attention. Researchers have achieved an ultra-strong and ultra-pure red upconversion in erbium and ytterbium co-doped lutetium oxyfluorides through size and morphology control. These nanoparticles, with extremely strong and pure upconversion are promising candidates as novel luminescent reagents for high-contrast bio-imaging and bio-labeling.
Biomineralization is the formation of inorganic materials in a biological environment, as it is found in bones, teeth and shells. Certain biominerals are also often associated with pathogeneses of tissues. The correlation of the composition of biominerals with pathogeneses of tissues has not been investigated systematically. In new work, researchers examine how the composition of biominerals correlates with the production of inflammatory cytokines associated with the stimulation of intracellular DNA sensors and by biominerals themselves.
Supramolecular chemistry deals with molecular building-blocks that interact with each other in a dynamic manner, similar to what is seen in nature. Taking advantage of this, several 'smart' materials have been developed for biomedical applications by careful design of these building-blocks. These materials have especially interesting properties like self-healing and responsiveness to light and electricity. Researchers have now explored the possibility of developing a bacterial strain with the ability to interact dynamically with a popular supramolecular building-block.