Currently in the clinic and in clinical development, there is heavy emphasis placed on understanding how drugs can be 'complementary'. That is to say, what combination of drugs will be most effective in killing tumor cells and overcome potential resistance mechanisms. In fact, adding synergistic combinations of drugs is reshaping how cancer is treated, even in the context of immunotherapy. A new study provides critical evidence that complementary drugs must be in spatial proximity to truly exert their synergistic potential.
Researchers have shown, using a mouse model of osteoarthritis, that curcumin loaded nanoparticles topically applied to arthritic knees stopped the progression of the disease and eliminated associated pain by locally delivering curcumin to the fat pad associated with the knee cap. The study also demonstrated several osteoarthritis relevant inflammatory pathways were suppressed by curcumin, including those that result in the production of proteins that destroy cartilage.
MoS2 nanosheets have shown great prospect as a near-infrared light (NIR) absorbing agent for PTT applications due to their unique photoelectric property, low cost and good biocompatibility. However, the absorbance of nanosheets in the NIR region is not specific and strong, and the photothermal conversion efficiency of MoS2 based materials need to be enhanced. In new work, researchers have proposed a novel MoS2 nanostructure, i.e. layered MoS2 hollow spheres (LMHSs), for improving their near-infrared absorption and photothermal conversion efficiency.
The manufacture of nanoparticles has reached a very high level of control of their shape, size and chemical nature. However, assembling nanoparticles in a controlled manner and with clearly defined functionalities in three-dimensional space remains quite a challenge. Researchers have now taken a first step towards the goal of protein-driven assembly of nanoparticles. In this ground-breaking work, they show that gold nanoparticles with a diameter of 10nm can be assembled using two different protein pairs.
Many virus detection platforms, including conventional fluorescent label-based ones, have limitations because they are time-intensive and not easily compatible with point-of-care use without the existence of significant infrastructure and expert staff. Researchers have now developed a technique capable of specifically visualizing label-free single viruses in complex solutions in real-time. This approach eliminates virtually all sample preparation.
The goal of a vast amount of nanomedicine research is the perfect drug carrier: it is injected into the body and transports itself to the correct target, such as a tumor, and delivers the required therapeutic drug dose at this target. This idealized concept was first proposed at the beginning of the 20th century and was nicknamed the 'magic bullet' concept. Taking this 'bullet' concept literally, researchers have developed acoustically triggered microcannons, capable of versatile loading and effective firing of nanobullets, as novel tools toward advancing microscale tissue penetration of therapeutic payloads.
Researchers have developed a suspended planar-array chip whose in situ capabilities with a spatial molecular-probe arrangement combine the advantages of both suspended arrays and planar arrays. This opens the way towards the multiplexed detection of intracellular biological parameters using a single device in dramatically reduced volumes, such as inside a living HeLa cell. The chip's volume represents only about 0.35% of the total volume of a typical HeLa cell.
Researchers have demonstrated a system that provides photo-triggered release of local anesthetics in a manner that could be adjusted by varying the irradiance and the duration of irradiation. From the clinical point of view, this is important in that it demonstrates a method by which patients would be able to take control of relatively local pain, being able to deliver local analgesia on demand, for the duration and with the intensity desired.