Nanomaterials for nanomedicine and biological applications are often two-component structures - referred to as 'nanoconstructs' -consisting of a 'hard' nanoparticle core and a 'soft' shell of biomolecular ligands. Researchers have now demonstrated a nanoconstruct with enhanced in vitro efficacy. This highly loaded nanoconstruct was taken up by pancreatic cancer cells and fibrosarcoma cells at fast rates. The team found that the increased loading of Apt on AuNS also resulted in an enhanced in vitro response.
Scientists have great expectations that nanotechnologies will bring them closer to the goal of creating computer systems that can simulate and emulate the brain's abilities for sensation, perception, action, interaction and cognition while rivaling its low power consumption and compact size - basically a brain-on-a-chip. Already, scientists are working hard on laying the foundations for what is called neuromorphic engineering - a new interdisciplinary discipline that includes nanotechnologies and whose goal is to design artificial neural systems with physical architectures similar to biological nervous systems.
Ice accumulation is not just a cost and safety problem for the airline industry and other transportation areas, together with undesired environmental impacts. Here are some examples: Transmission lines and power network towers may deform or even collapse with the burden of excess amount of ice; ice accretion on wind turbine blades can cause a production loss as much as 50% of the annual production; frost and ice accumulation in refrigerators and heat exchangers results in a decrease of heat transfer efficiency. Therefore, great efforts have been made to understand the mechanism of icing and investigations on anti-icing and deicing have been extensively carried out. Various anti-icing and deicing methods have been developed such as for instance nanocoatings and other nanostructured surfaces.
The investigation of effects of engineered nanomaterials on endothelial cells - which form the inner lining of blood vessels - is a critical safety issue. Already, various engineered nanomaterials are being designed for biomedical applications for intravascular use and other nanomaterials may reach the vasculature as a result of occupational, environmental, or other types of exposure. Researchers have now elucidated the mechanism of cytotoxicity of carboxylated MWCNTs on cultured endothelial cells and they show a new potential way of pharmacological cytoprotection against cytotoxic effect of carboxylated MWCNTs.
More serious than the common cold, influenza viral infection has been responsible for major epidemics and pandemic respiratory disease in communities around the world. These epidemics come with substantial morbidity and mortality, accounting for 250,000 to 500,000 worldwide deaths each year and are particularly dangerous for vulnerable and elderly populations with statistics showing that 90% of those who succumb to the severe illness are 65 years and older. The flu is also associated with high health care costs. In the U.S., more than $80 billion dollars is spent annually as a result of influenza epidemics.
Nanotechnology has made great strides in biology and medicine in the past year. Here is a list of the top 10 developments in Nanodermatology in 2013, as compiled by the Nanodermatology Society. These topics will be the subject of multiple talks and two sessions at the American Academy of Dermatology Annual Meeting on March 21-25, 2014 in Denver. This, however, is just a sampling of the topics to be covered and world class speakers in medical nanotechnology.
Biological barriers - the skin, mucosal membranes, the blood-brain barrier and cell/nuclear membranes - seriously limit the delivery of drugs into the desired sites within the body, resulting in a low delivery efficacy, poor therapeutic efficacy, and high cost. Nanomedicine researchers have developed numerous biological, chemical, and physical strategies to overcome these barriers. This article highlights recent advanced physical approaches for transdermal and intracellular delivery.
An artificial brain building program has created a process of circuit evolution similar to the human brain in an organic molecular layer. The research team has now finalized their human brain model and introduced the concept of a new class of computer which does not use any circuit or logic gate. The kind of CMOS based integrated chip that forms the core of existing supercomputers will not be used in this kind of computer. The team uses the term brain jelly to describe their purely organic computing architecture.