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PhD Thesis Student (m/f) Subject: Diffraction methods for membrane protein crystallography - Ref CFR382
Employer: ESRF
Location: Grenoble, France
Employment Start Date: As soon as possible

Organization Description:

The ESRF is a multinational research institute, situated in Grenoble, France and financed by 19 countries mostly European. It operates a powerful synchrotron X-ray source with some 30 beamlines (instruments) covering a wide range of scientific research in fields such as biology and medicine, chemistry, earth and environmental sciences, materials and surface science, and physics. The ESRF employs about 600 staff and is organized as a French société civile.

Job Description:

The elucidation of the structure of membrane proteins remains one of the most challenging types of protein crystallography. Despite many advances in the last decade each step of the process from identification of the target system through to the solubilisation and subsequently crystallisation and diffraction experiments remains replete with difficulties. This PhD position forms part of a set of initiatives directed to improving the instrumentation and methods available at the ESRF, and is undertaken with groups at the Institut de Biologie Structurale also based in Grenoble.

The PhD project will further the ESRF’s ability to handle the particular challenges to data collection afforded by membrane protein samples. The successful candidate will have the opportunity to work on a number of protein systems and will, through his/her PhD work, provide new methods for the visualization and location of multiple micro-crystals within a loop. The determination of data collection strategies from multiple, small, crystals will form a key element of the research work undertaken. Full training in crystallographic methods will be provided, and the successful candidate can expect to contribute to many experimental techniques.

Contract of two years renewable (subject to satisfactory progress) for one year. Monthly gross remuneration: 2286 €.


The working language of the ESRF is English. You should hold a degree in Physics, or Chemistry, permitting enrolment for a PhD, such as an MSc, Master 2 de Recherche, Laurea or equivalent.

Job Application:

For further information on employment terms and conditions, please refer to The ESRF is an equal opportunity employer and encourages applications from disabled persons.

If you are interested in this position, please apply on-line at this address:

Ref. CFR382 - Deadline for returning application forms:
18 March 2013

Date Posted: February 6, 2013