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Posted: Jul 14, 2014

Dolomite's New Microfluidic System Showcases Droplet Merging at Nanoliter Sample Scale

(Nanowerk News) Dolomite have released the Mitos Dropix® Droplet Merging System. It meets the needs of microfluidic applications that benefit from an advanced capability; the ability to combine pairs of droplets in a controlled manner. Applications include automated screening experiments (sample/screen pairing), dose-response testing (sample/diluent pairing to deliver to screen) concentration/stoichiometric testing (variation of mix ratio) and combinatorial chemistry (AnBn reagent pairings).
Droplet merging
Droplet merging using the Mitos Dropix® Droplet Merging System.
The system creates a droplet sequence and merges successive pairs of droplets using a microfluidic Droplet Pillar Merger Chip. In this device, a droplet can be held indefinitely in a trap until the next droplet in the sequence approaches. This feature allows for droplet fusion to occur, even if inter-droplet spacing does not remain constant. Using proprietary technology, the system performs automated and reproducible generation of nanoliter droplets from volumes of 40nL to 175nL, with consistent smooth flow generated by the Mitos Duo XS-Pump. The droplet merging process can be easily analysed by placing the Droplet Pillar Merger Chip on to the microscope stage provided, which allows image capture at speeds of over 1000fps via FireWire link to a desktop PC. Fluorinated solvents can be used with the system, making it ideal for bio processes that require gas dissolution and also insert separation of chemistry.
The approach of sequential merging greatly reduces the technical complexity of the assay and presents possibilities of multiple detection schemes in-line. The Mitos Dropix® Droplet Merging System further harnesses the complexity of such screening and simplifies it as a programmable flow-through process. There are no comparable automated continuous flow fluid handling systems currently available in the market, making it a highly desirable system that offers a complete solution for performing droplet merging.
The Dolomite Centre Limited
Established in 2005 as the world’s first Microfluidic Application Centre, Dolomite focused on working with customers to turn their concepts for microfluidic applications into reality. Today, Dolomite is the world leader in solving microfluidic problems. With offices in the UK and US and distributors throughout the rest of the world, its clients range from universities developing leading-edge analytical equipment, to manufacturers of chemical, life sciences and clinical diagnostics systems.
Dolomite is pioneering the use of microfluidic devices for small-scale fluid control and analysis, enabling manufacturers to develop more compact, cost-effective and powerful instruments. By combining specialist glass, quartz and ceramic technologies with knowledge of high performance microfluidics, Dolomite is able to provide solutions for a broad range of application areas including environmental monitoring, clinical diagnostics, food and beverage, nuclear, agriculture, petrochemical, cosmetics, pharmaceuticals and chemicals. Furthermore Dolomite's in-house micro-fabrication facilities that include clean rooms and precision glass processing facilities allow to prototype and test all solutions rapidly which ensures a faster development cycle and reduces the time to market. For more information please visit www.dolomite-microfluidics.com
Source: Dolomite (press release)
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