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Posted: Dec 17, 2014

Bruker Introduces BioScope Resolve High-Resolution BioAFM System

(Nanowerk News) Bruker announced the release of BioScope Resolve™, a biological atomic force microscope (bioAFM) that features the highest resolution imaging and most complete cell mechanics capabilities available for use with an inverted optical microscope (IOM). The system incorporates Bruker’s proprietary PeakForce Tapping® technology to enable researchers to achieve both the highest resolution imaging and piconewton level force measurements on biological samples.
BioScope Resolve also provides real-time correlation of atomic force microscopy and optical microscopy data sets to provide unique insights into life sciences research. Ultimately, BioScope Resolve enables imaging and mechanical property mapping of the biological detail of cells, tissues, and biomolecular structures never previously observed with a bioAFM on an IOM.
BioScope Resolve AFM
Bruker’s BioScope Resolve enables unrivalled bioAFM imaging resolution and cell mechanics capabilities on an inverted optical microscope.
“For the first time bioAFM analysis can directly correlate high-resolution molecular structures with function on the same cell,” said Dr. Lewis Francis of the College of Medicine and Center of NanoHealth at Swansea University, United Kingdom. “BioScope Resolve provides the dynamic range and resolution necessary to allow a deeper understanding of structure-function relationships at cell and tissue surfaces.”
“BioScope Resolve establishes a new benchmark for high-resolution imaging and cell mechanics characterization capabilities that are fully integrated with optical microscopy,” added David V. Rossi, Executive Vice President and General Manager of Bruker's AFM business. “It builds upon our exclusive and leading PeakForce Tapping technology to enable the highest performance bioAFM that researchers of every experience level will find very easy to use.”
“PeakForce Tapping provided my lab with the force control and resolution necessary to produce ground-breaking ligand-receptor interaction maps using functionalized probes on live cells in a very time efficient and controlled way,” commented Professor Dr. Daniel Muller of the Department of Biosystems Science and Engineering at the ETH Zürich, Switzerland, about his experience using PeakForce Tapping.
About BioScope Resolve
BioScope Resolve is an AFM developed specifically for integration with optical microscopy for biological research into cells, tissues and molecules. The new system provides the most complete range of capabilities for cell mechanics and molecular force spectroscopy. Its design enables the highest resolution imaging for all types of biological samples, from cells to biomolecules, making it the new benchmark in high-resolution bioAFM capability. In addition, BioScope Resolve has complete synchronization with the top inverted optical microscope brands, and provides single-button imaging using proprietary ScanAsyst® technology. Researchers can utilize the system’s quantitative PeakForce QNM® nanomechanics package to map the surfaces of soft biological samples. BioScope Resolve’s mechanical mapping capabilities bridge Force Volume and PeakForce QNM frequencies for the widest range available for force-distance curves on any AFM. BioScope Resolve also offers a full array of accessories to preserve the integrity of delicate samples, including carrier support with clear visual and physical access to samples, environmental control with heating and cooling capabilities, and a wide range of pre-calibrated biological probes.
Source: Bruker (press release)
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