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Posted: Aug 08, 2016

Protein cages for designing various catalytic reactions

(Nanowerk News) Compartmentalization is a common strategy used by living organisms to create isolated reaction environments to protect reaction catalysts from undesired reaction partners in cells. Mimicking such compartment systems is a novel approach for developing new biohybrid materials as well as for understanding the complex cellular processes.
Recently, the Ueno group at Tokyo Tech has developed a new strategy in which two different organometallic iridium (Ir) and palladium (Pd) metal complexes are immobilized into a single protein cage of apo-ferritin to construct a protein-based microcompartment ("Immobilization of two organometallic complexes into a single cage to construct protein-based microcompartments").
Schematic representation showing the crystal structure and catalytic reactions of apo-ferritin cage containing both Ir and Pd complexes
Schematic representation showing the crystal structure and catalytic reactions of apo-ferritin cage containing both Ir and Pd complexes.
The composite was prepared by the stepwise incorporation of Ir complex followed by introduction of Pd complex in buffer solution. The resulting protein composite was purified, crystallized, and characterized by X-ray crystallography.
The X-ray crystal structure analysis revealed that the Ir and Pd metal complexes have different binding preferences and to exist simultaneously inside the single protein cage. Notably, both the metal complexes are catalytically active and can promote cascade reactions such as Ir catalyzed hydrogenation and Pd catalyzed Suzuki-Miyuara cross-coupling reactions simultaneously inside the cage while keeping the entire cage structure intact.
The findings show that the concept of incorporating multiple metal catalysts into a single cage is promising for developing protein-based microcompartments and biomimetic materials for catalytic applications.
Source: Tokyo Institute of Technology
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