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Posted: Oct 14, 2016

Study finds surface texture of gallium nitride affects cell behavior

(Nanowerk News) Researchers at North Carolina State University have determined that the surface texture of gallium nitride (GaN) materials can influence the health of nearby cells. The work is significant because GaN is a material of interest for developing new devices that can control cellular behavior.
GaN materials have a unique suite of properties that make them viable candidates for bioelectronic devices: you can tune the charge on the surface of the materials; the materials don’t easily degrade in aqueous environments like the body; and they are nontoxic.
Surface Texture of Gallium Nitride Affects Cell Behavior
“But while living cells will survive in the presence of GaN, we wanted to know if we could influence the behavior of the cells by changing the make-up of the GaN material,” says Patrick Snyder, a Ph.D. student at NC State and lead author of a paper on the work (RSC Advances, "Nanoscale topography, semiconductor polarity and surface functionalization: additive and cooperative effects on PC12 cell behavior"). “Basically, we wanted to know if engineering the GaN could influence the health and metabolism of the surrounding cells.”
To do this, the researchers tested three different materials: GaN, and two variations of aluminum gallium nitride – Al0.8Ga0.2N and Al0.7Ga0.3N. The researchers manipulated the surface of the materials, creating rough and smooth versions of each. Lastly, the researchers modified the surface chemistry of the materials to make them more or less attractive to water – hydrophilic or hydrophobic, respectively.
For example, there were six types of GaN material: hydrophobic, hydrophilic and unmodified rough GaN; and hydrophobic, hydrophilic and unmodified smooth GaN. The same was also true for both compositions of AlGaN.
The researchers then used the various GaN materials as substrates for growing PC12 cells – a line of well-studied model cells that are well understood.
During the seven-day experiment, the researchers monitored the cell cultures to track the health and metabolism of the cells.
“We found that the roughly-textured AlGaN compositions released more gallium into the cellular environment,” Snyder says. “While this did not kill the cells, it did cause metabolic changes.”
“This tells us that the topography of the material matters, and can influence cellular behavior,” says Albena Ivanisevic, a professor of materials science and engineering at NC State and co-author of the paper. “The work demonstrates that surface textures of bulk materials – like those used to create devices – can have similar effects to what we’ve previously seen in nanoscale materials.”
Source: North Carolina State University
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