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Posted: August 4, 2009

The Importance of Acoustic Liquid Handling in Drug Discovery

(Nanowerk News) The most recent edition of the Journal of Biomolecular Screening, the world’s leading peer-reviewed publication on drug discovery sciences, focused on the significant advances made recently in the field of compound management. In this special edition over half of the sixteen articles specifically mention the Labcyte Echo® liquid handlers.
Of particular interest is the article by Grant et al., AstraZeneca, which states, “In summary, the introduction of the Echo acoustic reformatter has represented a major milestone in pharmaceutical screening applications. It has revolutionized the compound management process to support HTS.” (
In the paper by Zaragoza-Sundqvist et al., Astra Zeneca, the authors said, “Four years ago, the first acoustic droplet ejectors (ADEs) were launched on the market, providing a new generation of high throughput noncontact liquid handlers that outclassed traditional contact instruments in almost every respect...Higher quality is achieved through greater accuracy and precision, whereas lower sample volumes can be used, and 1536 plate formats have become a reliable reality.” (
Articles by Matson et al., Bristol-Myers Squibb, (, Pfeifer and Scheel, Novartis, ( and Blaxill et al., GlaxoSmithKline, ( use the acoustic auditing capabilities of the Labcyte Echo technology to determine the volume of wells and the level of DMSO hydration.
Labcyte Echo liquid handlers use sound to move a wide range of liquids. Eliminating physical contact with the sample makes the transfer contamination-free as well as extremely precise and accurate for a wide range of life science applications. The system has a working range from 2.5 nL to many microliters. Echo liquid handlers automatically measure the depth of fluid in each source well, informing the user of the quantity and quality of samples. This technology is especially well suited to biological applications in which precision measurements are critical and cross-contamination of samples can interfere with accurate interpretation of the results. Software especially designed for cherry-picking, dose-response set-up and plate reformatting, optimize the system ease-of-use.
About Labcyte
Labcyte Inc. uses sound to move liquids. This green technology provides significantly better analytical results while saving money. The ‘touchless’ technology provides dramatically better answers by eliminating pipette tips and the adsorption of compounds during transfer, while saving hundreds of thousands of dollars in decreased consumables. Accuracy is maintained from first drop through last for a wide variety of fluids, including many considered intractable by other techniques. The technology is coupled with our Deerac™ instruments to make Labcyte a leader in liquid handling. Together with the Deerac systems, the award-winning Echo® liquid handlers are used in all of the top 10 pharmaceutical companies, as well as in leading academic and research institutions worldwide. Labcyte technologies have broad applications including the fields of compound management, genomics, proteomics, particle manufacturing, encapsulation, imaging mass spectrometry, and live-cell transfer. Labcyte is headquartered in Sunnyvale, California with offices in Dublin, Ireland and has 39 U.S., 7 European and two Japanese patents and additional U.S. and international filings.
Source: Labcyte (press release)
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