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Posted: August 31, 2009

Correlative Microscopy in Materials Analysis; Carl Zeiss Presents Solution for Cross-Platform-Microscopy

(Nanowerk News) In time for the 2009 Microscopy Conference in Graz, Austria, Carl Zeiss is presenting an integrated solution for correlative microscopy in materials analysis. Core elements of the link between light microscopy and scanning electron microscopy (SEM) are the sample holder and adapter, as well as software for the fast, automated relocation and examination of one and the same region of interest in the light microscope as well as in the SEM. This solution, called “Shuttle & Find,” can be applied in both materials science as well as in many industrial routine procedures. Shuttle & Find will be widely available upon completion of the first applications that are being developed jointly with early customers. For the time being the solution is not suited for biological applications.
While light microscope images are based on reflection, or transmission, or fluorescence, the scanning electron microscope offers – in addition to the more than two orders of magnitude higher resolution – a variety of more in-depth analysis possibilities. These options primarily include the morphological characterization of the sample and the element analysis using X-ray spectroscopy (EDX). Initially, samples will be examined under a light microscope deploying various contrasting methods in bright field, dark field or using polarized light or interference. Interesting areas of the sample are then further examined in detail under the scanning electron microscope.
Mounting of the sample holder with the adapter into the vacuum chamber of a scanning electron microscope is as easy as 1-2-3.
Mounting of the sample holder with the adapter into the vacuum chamber of a scanning electron microscope is as easy as 1-2-3.
The “Shuttle & Find” solution from Carl Zeiss for correlative microscopy in materials analysis is an easy-to-use interface. It connects upright and inverted light microscopes of type SteREO Discovery, Axio Imager and Axio Observer, featuring a motorized stage, with all ZEISS scanning electron microscopes such as EVO, SIGMA, SUPRA, ULTRA and MERLIN, as well as the CrossBeam (FIB-SEM) workstations AURIGA, NVision and NEON. Within a few minutes, it is possible to transfer a sample from one system to the next. The sample can also be sent to another lab equipped with an SEM. In the SEM, the areas of interest of the sample examined are automatically relocated in a matter of seconds. In addition to numerous analyses which are based on separate images from light and electron microscopes the images of the two different instrument platforms can be precisely overlaid and correlated to X-ray maps to deliver further information.
Dr. Thomas Albrecht, Head of Product Management at Carl Zeiss SMT´s Nano Technology Systems division emphasizes: “As the only provider in the world to develop, produce and sell both light and electron microscopes, Carl Zeiss is predestined to develop solutions for correlative microscopy. With the interface presented today, we are taking a step which enables two largely separate worlds to come together. Our ´Shuttle & Find´ solution really means Bridging the Micro and Nano World”.
Carl Zeiss AG
Carl Zeiss AG is a leading group of companies operating worldwide in the optical and opto-electronic industries. The five independently operating business groups are active in the future-oriented markets of Medical and Research Solutions, Industrial Solutions and Lifestyle Products. Founded in 1846 in Jena, the company is headquartered in Oberkochen, Germany. Carl Zeiss AG is fully owned by the Carl Zeiss Stiftung (Carl Zeiss Foundation). During fiscal year 2007/08 (ended Sept. 30), the company generated revenues of EUR 2,731 million. Carl Zeiss has around 13,000 employees in more than 30 countries, including over 8,000 in Germany.
Carl Zeiss SMT AG
Carl Zeiss SMT utilizes its globally leading know-how in light, electron and ion-optical technologies to offer its customers in industry and R&D a broad portfolio of products, services and application solutions. The market-leading systems and solutions from Carl Zeiss SMT are used in mutually strengthening fields of application in nanotechnology such as semiconductor technology, materials research and the life sciences. The global customer community is constantly growing. As the innovation leader for lithography optics, as well as optical and particle-beam based inspection, analysis and measuring systems, Carl Zeiss SMT opens up new avenues for its customers in industrial manufacturing environments, quality assurance and industrial and university R&D. Together with its subsidiaries in Germany, England, France, the USA, Israel and Singapore, the international group of companies has over 2,500 employees. In fiscal year 2007/08, the wholly owned subsidiary of Carl Zeiss SMT AG generated revenues of over EUR 1,000 million.
Carl Zeiss MicroImaging GmbH
Carl Zeiss MicroImaging GmbH is a 100% subsidiary of Carl Zeiss AG. The leading manufacturer of microscope systems offers total solutions for biomedical research, the healthcare sector and high-tech industries. The product line spans a broad spectrum from light microscopes and systems for laser scanning microscopy and spectrometry to hardware and software for image processing and documentation.
Microscopes from Carl Zeiss allow scientists to gain important knowledge about diseases such as cancer, Alzheimer’s and tuberculosis. This results in new diagnostic techniques and better drugs for therapy. ZEISS microscopes support the development of new materials and enable more efficient quality inspection in industry.
Carl Zeiss MicroImaging GmbH is headquartered in Jena. Other manufacturing and development sites are located in Göttingen and Munich. During fiscal year 2007/08, the Microscopy Group at Carl Zeiss generated revenues of approximately EUR 340 million with a global workforce of about 1,700.
Source: Carl Zeiss (press release)
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