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Posted: September 17, 2009
Dolomite Enables Experiments With Nanoscale Volumes
(Nanowerk News) Dolomite, a world leader in microfluidic design and manufacture, has introduced the Mitos Wellplate for holding small reagent droplets or small groups of cells.
With a 40 x 40 array of nano-litre wells, each standard plate has a well volume of 0.26 nl to enable experiments to occur using nanoscale volumes.
Covering a small area of 10 x 10 mm, the array of wells is designed to fit onto a microscope slide and under a standard coverslip. The wet etching process provides a surface roughness of <5 nm, enabling easy access for microscopy systems. Furthermore, with a depth of 2 mm, the wellplate provides excellent optical transmission for clear observation of each well.
With the ability to be etched to a range of depths or diameters, as required, each well can be customized to offer alternate volumes and two layers can be used to form more complex geometries. The surface of the chip is naturally hydrophilic; however custom coatings are available, which include a hydrophobic, gold or platinum layer that can be applied to the surface of the well.
The pump can operate directly with either de-ionised water or methanol, however using indirect methods such as using a sample loop between the pump and the on-chip working area, the Micro Electro-Osmotic Pump can be used with any liquid.