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Posted: April 21, 2010

Microfluidics Introduces Revolutionary Bottom-up Technology as a Platform for Continuous Pharmaceutical Manufacturing

(Nanowerk News) At INTERPHEX 2010 (April 20-22, NYC), Microfluidics International Corporation, a leader in pharmaceutical nanomaterials processing, will introduce Microfluidics Reaction Technology™ (MRT) as a cutting-edge platform for continuous pharmaceutical manufacturing. Combining a unique high shear fluid processor with expert process development, MRT is a revolutionary technology for bottom-up nanoparticle creation:
  • Continuous crystallization for production of highly crystalline drug nanoparticles
  • Multiphase chemical reactions
  • Nanoencapsulation of actives
  • Process intensification
  • MRT enables companies to transform their manufacturing processes from batch to continuous in order to drastically reduce the time and cost of commercial drug production. By creating nanoparticles bottom-up and controlling their growth, MRT allows research teams to create stable and consistent nanoemulsions, for example, at previously unattainable sizes and narrow distributions (e.g. Azithromycin with a z-average particle size of 82 nm).
    Microfluidics will describe the technology in greater detail at its press conference on Wednesday, April 21, 8:30 AM, at INTERPHEX 2010, Jacob K. Javits Convention Center in New York City. POWREX Corporation, the exclusive distributor of Microfluidics technology in Japan, will also speak at the press event on bringing MRT to Asia.
    “According to an independent 2010 survey that we commissioned, 80 percent of pharmaceutical companies plan to invest in continuous crystallization technology,” said Michael C. Ferrara, President and CEO of Microfluidics. “MRT is the technology they are seeking. It has the potential to revolutionize pharmaceutical production by serving as a scalable platform for continuous manufacturing and by enabling pharma companies to make purer, more consistent drugs faster with improved stability and bioavailability.”
    The technology has immediate value in the pharmaceutical, biotechnology and energy industries. Some of the applications ideal for MRT include more effective and tailored drugs, more efficient catalysts for fuel cells, and nanomaterials for batteries, photovoltaics and supercapacitors.
    "MRT allows companies to improve bioavailability, target delivery and encapsulate actives more efficiently than any top-down process or traditional crystallization method," said Thomai “Mimi” Panagiotou, PhD., Microfluidics Chief Technology Officer. “Currently, the typical batch crystallization process involves several steps, often in locations across the country, which can take weeks. MRT simplifies the process and has been proven to reduce production time to a matter of hours. Its innovative capabilities for continuous crystallization and chemical reactions have the potential to transform the manufacture of drugs and chemicals by significantly streamlining the steps, timing and cost of consistent, continuous large-scale commercial production.”
    To learn more about MRT attend the Microfluidics INTERPHEX press conference, visit the company’s Interphex Booth #2214 or contact Kris Sarajian at ksarajian(at)mfics(dot)com or (+1) 617.969.5452 x233.
    About Microfluidics
    Microfluidics is the exclusive producer of Microfluidizer® high shear fluid processors for uniform particle size reduction, robust cell disruption and bottom-up nanoparticle creation. Used primarily by pharmaceutical, biotechnology, chemical, cosmetic, nutraceutical/food and energy companies to research, develop and improve products with efficient processes, more than 3,000 Microfluidizer processors are installed at customer sites in 50 countries around the world. The innovative Microfluidics Technology Center, located at the company’s headquarters outside Boston, Mass., is staffed by expert engineers with a wide range of nanotechnology and application experience for Proof of Concept and Process Development services.
    By producing smaller particle sizes and a more narrow distribution than other technologies, with scaleup from lab to production guaranteed, Microfluidics enables companies to create tiny particles that achieve big results.
    Source: Microfluidics (press release)
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