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Posted: Aug 16, 2011

Hybrid Plastics Achieves Milestone with a POSS Enabled Synthetic Trachea Inserted in a Human Subject

(Nanowerk News) Medical history was made in 2011 with the world's first synthetic organ transplant. A terminally ill cancer patient received a new lease on life with the transplant of a synthetic trachea made from a POSSŪ nanocomposite polymer. Seeded with the patient's own stem cells, the inert POSSŪ polymer windpipe scaffold became an organ indistinguishable from a normal healthy one. The patient's body accepted the POSSŪ polymer trachea with no infection or inflammation, and without the need for strong anti-rejection drugs. POSSŪ acted as the enabling agent allowing the stem cells to bond to the compound.
The composite made from POSSŪ and PCU (Polyhedral Oligomeric Silsesquioxane & Poly (carbonateurea) Urethane) had been developed by Dr. Alex Seifalian of the University College London Medical School. The effort has been so effective that Dr. Seifalian says he now has six more tracheas on order. Representing a pioneering step in the history of transplantation, the importance of the new technique is that there's no need for a donor. Moreover the composite scaffold can be transformed into a human artery, vein, heart valve, tear duct or trachea. It might in the future be used to make larynxes, noses, breasts, ears or other parts of the human body.
Hybrid has developed a platform technology called POSSŪ (Polyhedral Oligomeric Silsesquioxane). It is a revolutionary new Nanotechnology based on silicon-derived building blocks that provide nanometerscale control to dramatically improve the properties of traditional polymers. They release no VOCs and, thereby, produce no odor or air pollution. They are biocompatible and recyclable. POSSŪ nanoscopic chemical technology provides unique opportunities to create revolutionary material combinations through a melding of the desirable properties of ceramics and polymers at the 1 nm length scale. These new combinations enable the circumvention of classic material performance trade-offs by exploiting the synergy and properties that only occur between materials at the nanoscale.
The company is ISO 9001:2008 certified and has received a Frost and Sullivan Best Practices Award. Frost & Sullivan stated "Hybrid Plastics' customer service is unparalleled in the high performance fillers market." Hybrid Plastics was one of five finalists in Small Times Magazine's 2002 Best of Small Tech Award. The company has received two R&D 100 Awards, most recently in 2009. In December 2005, a Presidential Determination deemed POSSŪ Nanotechnology to be in the strategic national interest of the United States. Investments made through Title III of the Defense Production Act supported the development and commercialization of this technology.
For More Information Contact: Carl Hagstrom, Chief Operating Officer
Source: Hybrid Plastics (press release)
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