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Posted: Aug 16, 2011

Detecting Sub-Nanometre Molecules at Low Concentrations

(Nanowerk News) Avid Nano have issued a new technical note demonstrating the excellent performance of its W130i Dynamic Light Scattering System for detecting and precisely measuring sub-nanometre particles and molecules.
The new technical note describes the ease with which a very small molecule with a low molecular weight (caffeine, MW 194.2 g/mol) was accurately measured at only 1.4% concentration in aqueous solution.
The results using the W130i DLS demonstrate that the light scattering signal from the dissolved caffeine is sufficient to produce a good quality correlogram with an intercept >0.2 and highly reproducible data with low polydispersity. The mean radius was consistently reported at about 0.48nm and molecular weight estimate around 400Da indicating concentration dependent self association into dimers, a known characteristic of caffeine in aqueous solutions.
Engineered to meet the demands of today's research laboratories, the W130i dynamic light scattering system delivers outstanding performance from only microlitres of sample in seconds. The W130i combines ultimate measurement performance with an economical benchtop footprint, rugged durability and supreme user convenience.
For a copy of Technical Note 1107-T4 please visit www.avidnano.com/downloads/downloads.htm or contact Avid Nano on +44-1494-614659 or email info@avidnano.com.
Dynamic light scattering is a non-invasive technique that enables quick and accurate measurement of hydrodynamic radius, size distribution, estimated molecular weight and aggregate content of biomolecules and nanoparticles in solution or suspension. Avid Nano DLS systems find particular utility in applications including crystal screening, buffer optimisation, solubility screening, aggregate detection, micelle formation, engineered nanoparticles and formulation development.
Operating from its UK headquarters - Avid Nano is building a strong reputation for its technical expertise, applications support and delivering DLS systems that reliably deliver top quality results.
Source: Avid Nano (press release)
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