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Posted: Feb 14, 2012

Dolomite And GigaGen Inc. Develop Novel Droplet Merging Technology

(Nanowerk News) Dolomite, a world leader in the design and manufacture of microfluidic systems and devices, has announced its collaboration with GigaGen Inc. (San Francisco, CA) in the development of a novel Droplet Merger Chip for massively parallel single cell genetic analysis.
Measuring just 15mm x 22.5mm, the novel glass microfluidic chip facilitates fast and consistent merging of two individual droplet streams, benefiting a wide range of applications including DNA amplification, biochemical analysis, single cell analysis and high throughput experimentation. Unlike other methods which incorporate expensive and bulky high voltage electronics to merge droplets using electrostatic forces, the Droplet Merger Chip works by simply "squeezing" droplets together in a carefully designed merging chamber.
The result is a unique microfluidic device, which points the way to low cost disposable chips in future versions. "A simple and reliable droplet merging technology is an important step forward for us", said Dr. David Johnson, CEO and founder of GigaGen Inc., adding "We are now using these chips in our game-changing system for massively parallel single cell genetic analysis." GigaGen Inc. filed a patent application describing the chip design and its applications in the field of genetic analysis of cells.
Droplet merging of two individual droplet streams in the new Droplet Merger Chip
Droplet merging of two individual droplet streams in the new Droplet Merger Chip.
As part of a license agreement with GigaGen Inc., Dolomite will be offering the technology later this year to research users in academia and commercial users in a wide range of application areas. "Many of our customers have asked us for chips to create droplets, merge them, and then carry out further processing and analysis", commented Dr. Andrew Lovatt, CEO of Dolomite. "Our partnership with Sphere Fluidics gives us additional capability in selecting the surfactants we use, to optimize droplet behaviour and stability under a wide range of temperature and biological conditions."
For more information go to http://www.labtube.tv/channel.aspx?u=dolomite to watch Dolomite's droplet merging video. For further information on Dolomite's complete portfolio of microfluidic products including chips, connectors/ interconnects, valves, pumps and custom devices please visit www.dolomite-microfluidics.com.
The Dolomite Centre Limited
Established in 2005 as the world's first Microfluidic Application Centre, Dolomite focused on working with customers to turn their concepts for microfluidic applications into reality. Today, Dolomite is the world leader in solving microfluidic problems. With offices in the UK and US and distributors throughout the rest of the world, its clients range from universities developing leading-edge analytical equipment, to manufacturers of chemical, life science and clinical diagnostics systems.
Dolomite is pioneering the use of microfluidic devices for small-scale fluid control and analysis, enabling manufacturers to develop more compact, cost-effective and powerful instruments. By combining specialist glass, quartz and ceramic technologies with knowledge of high performance microfluidics, Dolomite is able to provide solutions for a broad range of application areas including environmental monitoring, clinical diagnostics, food and beverage, nuclear, agriculture, petrochemical, cosmetics, pharmaceuticals and chemicals. Furthermore Dolomite's in-house micro-fabrication facilities that include clean rooms and precision glass processing facilities allow to prototype and test all solutions rapidly which ensures a faster development cycle and reduces the time to market. For more information please visit www.dolomite-microfluidics.com.
Source: Dolomite (press release)
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