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Posted: Feb 13, 2006

German researchers design hybrid bio-synthetic nanoparticles to fight cancer

(Nanowerk News) They are only a few nanometers in size, but their impact is tremendous: The tiny particles drive cancer cells to their death in no time at all. At nano tech 2006 in Japan from Feb. 21-23 researchers from the German Fraunhofer-Gesellschaft will demonstrate in Hall 4 the great efficiency of nanoscopic particles as a vehicle for drug delivery.
Medicines that will make their own way through the body and attack precisely the diseased cells on reaching their destination – such has been the dream of physicians and pharmacists since time immemorial. Fraunhofer researchers working in the Fraunhofer Nanotechnology Alliance have now come a little closer to reaching this goal. They have developed bio-functional nanoparticles that cause necrosis in cancer cells. "These cell-like structures have a solid nucleus surrounded by proteins that detect and destroy cancer cells," explains Dr. Günter Tovar of the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB.
Nanocytes® (red colored) attach to a target cell (with green-colored proteins inside) and cause its destruction. Above: after 20 minutes; below: after 40 minutes (Source: Fraunhofer-Gesellschaft)
So how does it work? "Communication in the human body is a biochemical process based on the exchange of molecules," says Tovar. "We are trying to understand these communication processes and harness them for our own purposes." The tumor necrosis factor TNF for instance, releases a molecule that attaches itself to the receptors of the cancer cell and passes on its deadly message. To introduce the biological messenger TNF into the body, Tovar and his colleagues at Stuttgart University have developed bio-functional nanoparticles. Known as nanocytes®, these carry TNF proteins on their surface. "In producing these particles, we benefit from the self-organizing capability of the 'building blocks': Once a contact has been established between the particles and the proteins, the proteins grow and envelop the nuclei without any further effort on our part," the researcher explains. Tovar tested the finished nanoparticles in a Petri dish. His findings were most encouraging: cancer cells that came into contact with the particles did indeed perish. The researchers documented this process on video, and will be showing the film at the Fraunhofer stand at nano tech 2006.
It will be a while before nanocytes® can be used in the battle against cancer. First of all, a great deal of time and effort must be invested in clinical studies. But meanwhile the bio-functional nanoparticles have already proved their mettle in practical applications – as a tool for cell research or as a component in reagents for medical analysis.
Source: Fraunhofer-Gesellschaft