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Posted: April 24, 2008

Arrowhead Nanobiotechnology Subsidiaries, Calando Pharmaceuticals and Insert Therapeutics, Complete Merger

(Nanowerk News) Arrowhead Research Corporation announced today the completion of the merger between Insert Therapeutics, Inc. and Calando Pharmaceuticals, Inc. The merger is part of a streamlining of the two companies in which Arrowhead assumed active management to increase efficiency and focus resources on bringing multiple products to the clinic as rapidly as possible. The merged company will do business under the name “Calando Pharmaceuticals, Inc.”
“Both Calando and Insert are on track to maximize value from their core technologies and each has recently announced progress toward additional clinical trials,” said Christopher Anzalone, Arrowhead’s CEO. “The companies are built around very similar platforms and we saw compelling reasons to merge them into a single, more efficient entity. We believe the result will be a leaner and stronger company going forward with multiple compounds in clinical development.”
Calando has an active clinical program that spans small molecule and siRNA therapeutics for the treatment of cancer. Calando’s IT-101 compound is moving into phase II clinical trials for the treatment of ovarian cancer. Calando’s CALAA-01 has been cleared by the FDA to begin phase I clinical trials and is on track to be the first use of siRNA for the treatment of cancer in humans.
About Arrowhead Research Corporation
Arrowhead Research Corporation ( (NASDAQ:ARWR) is a leading nanotechnology company commercializing new technologies in the areas of life sciences, electronics and energy. Arrowhead is building value for shareholders through the progress of majority owned subsidiaries founded on nanotechnologies originally developed at universities. The company works closely with universities to source early stage deals and to generate rights to intellectual property covering promising new nanotechnologies. Currently, Arrowhead has five subsidiaries commercializing nanotech products and applications, including anti-cancer drugs, RNAi therapeutics, fullerene anti-oxidants, carbon-based electronics and compound semiconductor materials.
About Calando Pharmaceuticals Inc. and Insert Therapeutics, Inc.
Calando Pharmaceuticals, Inc. is a biopharmaceuticals company using proprietary technologies developed by Professor Mark Davis at Caltech to deliver targeted siRNA and small molecule therapeutics. Calando combines its innovative RONDEL™ system of polymeric delivery with siRNA to solve the long-standing obstacle of effective delivery and targeting for this revolutionary new field of medicine using RNA interference, or “RNAi.” Based upon the innovative breakthrough in siRNA delivery enabled by the RONDEL™ system, the potential of using siRNA in new systemic therapies, upstream from the mode of action of most drugs today, may finally be realized.
Insert’s lead therapeutic candidate, IT-101, composed of its Cyclosert™ delivery technology and a small molecule anticancer agent – camptothecin, is currently in a phase 1 trial at City of Hope in Pasadena, CA. The combined company plans to continue its development of RONDEL™ and Cyclosert™ through both internal R&D and in collaborations and partnerships with pharmaceutical and biotechnology companies. Calando expects that it will enter into collaborations with other companies working in the siRNA field to combine our delivery system with their siRNA to advance other innovative treatments for indications in oncology, viral infections, CNS, and metabolic and autoimmune diseases, among others.
Source: Arrowhead Research Corporation
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