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Posted: September 12, 2008
Quadrupole DNA sequencing
(Nanowerk News) Research at Oak Ridge National Laboratory is exploring how a system of nanotubes, magnets and electrically charged particles could lead to a quicker, cheaper way to conduct DNA sequencing.
The project headed by Predrag S. Krstic of ORNL's Physics Division will use a nanoscale quadrupole Paul trap, a component of a mass spectrometer that captures ions in an electromagnetic field, to develop a high speed DNA sequencing device.
Using the Paul trap to manipulate DNA between nanotube electrodes could result in a lower cost alternative to nanopore sequencing, which works by moving strands of DNA through a small hole in a membrane.
Most of the work is being conducted in collaboration with the Mark A. Reed Research Group of Yale University. The research is funded by $722,000 from the National Human Genome Research Institute, part of the National Institutes of Health.
The program seeks to cut the cost of whole-genome sequencing from millions of dollars to $1,000 or less, making individual genome sequencing cost-feasible for routine medical care.