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Posted: November 17, 2008

New Cell-Based Assays Provide Greater Sensitivity for Cytotoxicity Analyses

(Nanowerk News) Millipore Corporation has announced the launch of new high content analysis kits for detecting neurotoxicity. The kits are designed for use in drug discovery and basic neuroscience research.
The kits identify toxicity biomarkers in neurons and glial cells. Detection of these markers may provide molecular and cellular signatures predictive of toxic effects on the nervous system. These kits can be used in many areas of neurological study including Alzheimer’s disease, Parkinson’s disease and other neurodegenerative disorders. The products reflect Millipore’s expertise in high content analysis, neuroscience and in developing multi-parameter, biomarker-based assays.
Dr Stella Redpath, Group Product Manager at Millipore said, “We are very excited at the release of this family of kits, which are the first high content analysis kits for co-culture cells (neurons and astrocytes). They are also the first such kits shown to improve detection sensitivity for neurotoxins compared to traditional assays such as MTT and LDH.”
In pharmaceutical development, using improved assays for toxicity assessment alongside other ADMET methods– may reduce the chances of unexpected adverse toxic effects at later stages of the process. The kits have been developed by Millipore as a continuation of their portfolio of innovative discovery toxicology products
Co-culture of primary rat hippocampal neurones and astrocytes
Co-culture of primary rat hippocampal neurones and astrocytes. Neurons were detected with antibodies against b III tubulin (green) and astrocytes with antibodies against GFAP (red). Cell nuclei are stained with Hoescht dye (blue). Images were taken with a GE Healthcare IN Cell 1000 Analyzer.
About Millipore
Millipore is a Life Science leader providing cutting-edge technologies, tools, and services for bioscience research and biopharmaceutical manufacturing. As a strategic partner, we collaborate with customers to confront the world’s challenging human health issues. From research to development to production, our scientific expertise and innovative solutions help customers tackle their most complex problems and achieve their goals. Millipore Corporation is an S&P 500 company with 6,000 employees in 47 countries worldwide. For more information, please contact Millipore Tech Service at 1-800-548-7853 or 951-676-8080 or visit
Source: Millipore (press release)
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