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Posted: December 17, 2008
Nanion's Port-a-Patch is Used for Bilayer Research and Education at the Technical University of Munich
(Nanowerk News) Starting in 2008, Nanion’s Port-a-Patch is being
used in education and research at the Institute for Biomolecular Systems and
Bioelectronics, Department of Physics at the Technical University of Munich. Because
of its ease of use and the high quality data generated, the Port-a-Patch is of great
value in basic biophysical research and hands-on education of students.
“The Port-a-Patch allows students and researchers with no prior experience in electrophysiology to
rapidly generate research grade data. Within the courses given at the Institute for Biomolecular Systems
and Bioelectronics, the students gain hands-on experience in basic membrane biophysics and
electrophysiology which is of great value for their education.” says Professor Simmel, who holds the
Chair of Bioelectronics at the TU Munich Physics Department. His group is devoted to research in
bionanotechnology, systems biophysics, and bioelectronics.
Nanion’s automated patch clamp system, the Port-a-Patch, is recognized as the world’s smallest patch
clamp device, allowing for ultralow noise recording of single ion channel events in artificial as well as
cellular bilayers, in addition to whole-cell recordings. Using Nanion’s Vesicle Prep Pro, giant unilamellar
vesicles (GUVs) are produced, into which the ion channels of interest are reconstituted. The GUVs,
containing ion channels, are used to form high-resistance, solvent-free bilayers, using the Port-a-Patch.
The procedures of bilayer formation and protein introduction are greatly simplified, increasing the
efficiency of the research, as well as drastically increasing data quality compared to other recording
techniques, such as the use of black lipid membranes.
“We are excited to hear that our products enable students to discover a very broad and interesting
field of academic research, which historically has been quite difficult to access and is known to have a
notoriously low throughput. As a leading provider of tools for ion channel research, we have also
noticed an increased interest from industry users for bilayer recordings.” says Niels Fertig, CEO of Nanion.
Nanion Technologies GmbH is a German Private Limited Company and was founded in 2002 as a spinoff
from the Center for Nanoscience (CeNS) of the University of Munich. Nanion’s team has developed
and globally established two highly successful automated patch clamp instruments as enabling tools for
sophisticated and high throughput applications for ion channel research and drug discovery.
Nanion's instruments use planar patch clamp chips which replace the traditional glass pipette used in
the technique of patch clamping. Following the successful market introduction of two automated
patch clamp devices, the Port-a-Patch (2004) and the Patchliner (2006), Nanion now introduces a
massively parallel patch clamp platform, the SyncroPatch 96. Nanion was nominated in 2007 for
Germany's most prestigious innovation award the Deutscher Zukunftspreis (German Future Prize, Federal
President's Award for Technology and Innovation).