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Posted: Nov 13, 2015
Engineers develop 'killer cells' to destroy cancer in lymph nodes
(Nanowerk News) Cornell biomedical engineers have developed specialized white blood cells - dubbed "super natural killer cells" - that seek out cancer cells in lymph nodes with only one purpose: destroy them. This breakthrough halts the onset of metastasis, according to a new Cornell study published this month in the journal Biomaterials ("Super natural killer cells that target metastases in the tumor draining lymph nodes").
A robust amount of the therapeutic, cancer-killing TRAIL protein, shown in green, bound to the surface of natural killer cells - making them "super natural killer cells" - collected from the mouse lymph node 24 hours after treatment.
"We want to see lymph node metastasis become a thing of the past," said Michael R. King, the Daljit S. and Elaine Sarkaria Professor of Biomedical Engineering and senior author of the paper.
For tumor cells, the lymph nodes are a staging area and play a key role in advancing metastasis throughout the body. In the study, the biomedical engineers killed the cancerous tumor cells within days, by injecting liposomes armed with TRAIL (Tumor necrosis factor Related Apoptosis-Inducing Ligand) that attach to "natural killer" cells -- a type of white blood cell -- residing in the lymph nodes.
King says these natural killer cells became the "super natural killer cells" that find the cancerous cells and induce apoptosis, where the cancer cells self-destruct and disintegrate, preventing the lymphatic spread of cancer any further.
"In our research, we use nanoparticles - the liposomes we have created with TRAIL protein - and attach them to natural killer cells, to create what we call 'super natural killer cells' and then these completely eliminate lymph node metastases in mice," said King.
In cancer progression, there are four stages. At stage I, the tumor is small and has yet to progress to the lymph nodes. In stages II and III, the tumors have grown and likely will have spread to the lymph nodes. At the stage IV, the cancer has advanced from the lymph nodes to organs and other parts of the body.
Between 29 and 37 percent of patients with breast, colorectal and lung cancers are diagnosed with metastases in their tumor-draining lymph nodes - those lymph nodes that lie downstream from the tumor, and those patients are at a higher risk for distant-organ metastases and later-stage cancer diagnoses.
In January 2014, King and his colleagues published research that demonstrated by attaching the TRAIL protein to white blood cells, metastasizing cancer cells in the bloodstream were annihilated.
"So, now we have technology to eliminate bloodstream metastasis - our previous work - and also lymph node metastases," King said.