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Transforming skin cells to insulin

(Nanowerk News) Researchers at the University of Bergen have transformed skin puncture cells from diabetes patients into insulin producing cells, using stem cell techniques (Scientific Reports, "Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells").
Helge Rader, University of Bergen
Professor Helge Ręder is one of the scientists in the global race, trying to succeed producing artificially made insulin-secreting cells to treat diabetes patients.
The researchers' aim is to transplant these cells under the skin of people with diabetes.

"This study is a step towards discovering how "stand-in" cells can secrete insulin in the body," says Professor Helge Ręder, leader of the stem cell node at the K.G. Jebsen Centre for Diabetes Research, University of Bergen.

Automatic insulin regulation


In the long run, the researchers“ goal is to replace insulin shots and blood sugar measurements with insulin-secreting cells capable of automatically secreting insulin in response to the blood sugar level. This can become possible by implanting a capsule with tailor made cells in each diabetes patient.

"Our study is a step further in the spare part or regenerative medicine, where a lot may go wrong but where a successful approach may cure diabetes," Ręder says.
Today, there is an ongoing race between scientists trying to restore insulin secretion within the human body in diabetes patients, by artificially created insulin-producing cells.
"There is a big marked out there for those who can commercialize successful treatment with this approach. Today 400 million people have diabetes worldwide," Professor Helge Ręder underlines.
Source: The University of Bergen
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