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Posted: Jul 17, 2012

Genisphere Adapts 3DNA Dendrimer Technology to Lateral Flow Point-of-Care Assays

(Nanowerk News) Genisphere has adapted its pioneering 3DNA Dendrimer Signal Amplification technology for Lateral Flow (LF) Point-of-Care (POC) assays, providing improved sensitivity and enabling a broad new array of POC tests. LF assays represent a unique and growing class of POC tests designed to rapidly diagnose patients within clinically actionable timeframes.
Genisphere’s 3DNA® signal amplifiers will enable the commercialization of new LF assays that otherwise could not be launched due to unacceptably low sensitivity and will help test-makers differentiate themselves in the competitive POC testing market, which is flooded with products that are limited by both sensitivity and quantitative accuracy.
These developments build on previous signal amplification capabilities that have been demonstrated in other systems such as ELISA, protein and DNA arrays, as well as Luminex® assays. Genisphere will showcase its technology at the 2012 American Association for Clinical Chemistry Annual Meeting and Clinical Lab Expo (Booth 246), to be held July 15-19 in Los Angeles.
“Genisphere’s game-changing 3DNA® technology provides an improvement of sensitivity in lateral flow assays that no other system has been able to achieve,” said Jim Kadushin, vice president and chief operating officer, Genisphere. “Genisphere has accomplished its goal of providing a robust and easy-to-use reagent that manufacturers can drop into their existing bioassay platform with very little adaptation and no end user modifications required. We look forward to exploring a range of strategic partnering opportunities.”
Genisphere’s proprietary 3DNA® Dendrimer technology has delivered up to 64-fold improvements in sensitivity over standard, non-dendrimer assays. With this heightened power of detection, the technology can reduce false negatives and significantly increase the accuracy of otherwise-subjective outcome readings. (A technical note is available for download at: www.genisphere.com/pdf/POC-Tech-Note-16July2012.pdf)
The technology will expand the POC market to more sensitive rapid-testing for a wide list of conditions such as infectious diseases, bacterial sepsis, coronary biomarkers, food microbiological testing, and environmental and water testing that are outside the analytical reach of current systems.
About Genisphere
Genisphere LLC is a privately held company driven by a mission to apply its proprietary technologies and scientific expertise to multiple applications that will improve the human condition through research, diagnostic and therapeutic solutions. As an established leader in the development and commercialization of kits and reagents used for the detection of nucleic acids and proteins, Genisphere’s solutions are primarily based on the Company’s proprietary whole transcriptome RNA Amplification processes, miRNA labeling methodologies, and 3DNA® Dendrimer Nanotechnology. These combined technologies permit the interrogation and ultra-sensitive detection of a wide range of biomolecules, on a variety of detection platforms, including microarrays, flow and bead based assays, ELISAs, lateral flow assays and RNA sequencing. Genisphere is also applying its technology portfolio to the future development of diagnostic and therapeutic applications. For more information on Genisphere, please visit the company’s website at www.genisphere.com.
Source: Genisphere (press release)

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