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Posted: Sep 04, 2012
Realizing the promise of RNA nanotechnology for new drug development
(Nanowerk News) The use of RNA in nanotechnology applications is highly promising for many applications, including the development of new therapeutic compounds. Key technical challenges remain, though, and the challenges and opportunities associated with the use of RNA molecules in nanotechnology approaches are presented in a review article in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc.
Peixuan Guo and colleagues, University of Kentucky, Lexington, highlight the ability of RNA to self-assemble into nanoparticles with diverse structures. In “Uniqueness, Advantages, Challenges, Solutions, and Perspectives in Therapeutics Applying RNA Nanotechnology” (free access), the authors provide a detailed description of the main challenges faced by the RNA therapeutics industry, including the chemical and thermodynamic instability of the molecules, potential safety and side effect issues, difficulties in delivery and specific targeting, and low yield and high production costs in manufacturing.
“The remarkable structural and enzymatic properties of RNA continue to astound us,” says Executive Editor Fintan Steele, PhD, SomaLogic, Inc., Boulder, CO. “It is exciting to see those properties increasingly realized for the benefit of human health and welfare, as described by Dr. Guo and his colleagues.”