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Posted: Feb 27, 2013

Using AFM and the Tip Assisted Optics Module to Study Individual Nanotubes and Fibrils

(Nanowerk News) JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the research studies of Dr Ioan Notingher, associate professor in the faculty of science at the University of Nottingham. With a research interest in the development of new optical and spectroscopic methods for studying biomaterials, he is applying JPK's atomic force microscope (AFM) system, the NanoWizardŽ, and tip assisted optics module (TAO).
The research programmes of the Nottingham Nanoscience group span a range of exciting and topical themes in state-of-the-art nanoscale science. Housed in a suite of recently refurbished laboratories containing an excellent equipment base, their core activities are focussed on understanding and controlling the structure and behaviour of condensed matter on length scales ranging from the single molecule limit to micron dimensions.
Faris Sinjab is a PhD student in the group of Dr Ioan Notingher
Faris Sinjab is a PhD student in the group of Dr Ioan Notingher is seen using the JPK NanoWizardŽ AFM system.
Dr Ioan Notingher is interested in the development of new optical and spectroscopic methods for studying biological materials at a nano and micro-scale. The main aim of his research is to understand the supramolecular architecture of self-assembled peptide and protein nanostructures. Understanding the interactions between the molecules is crucial for optimising the physical, chemical and biological properties of these unique materials for biomedical applications such as advanced drug delivery, tissue engineering or biosensing. At the same time, nanoscale investigations of the molecular properties of self-assembled peptide nanotubes will advance the understanding of intermolecular interactions which lead to neurogenerative diseases. Such fundamental understanding at the molecular level is required for developing new therapies and preventive strategies.
The addition of AFM and TAO from JPK allows Dr Notingher and his colleagues to focus their investigations on individual nanotubes or fibrils. This is very important because these nano materials have a high heterogeneity in terms of size and shape. Therefore, techniques which require a large number of tubes cannot be used as they provide averaged results which cannot be extrapolated to individual nanotubes. Other techniques such as electron microscopy were limited to morphological studies. Complementary is the information brought by AFM and the optical spectroscopy techniques which allow more detailed investigations at a molecular level, such as studies of hydrogen bonding and molecular orientation.
Speaking of the benefits of the JPK NanoWizard AFM, Dr Notingher said "It allows us to integrate with optical spectroscopy. This means the size/shape and mechanical properties can be measured by AFM and vibrational spectroscopy can be performed on the same nano- or micro-tube. The TAO allows full control over AFM tip. For example, in the case of tip-enhanced Raman spectroscopy, the tip can be aligned accurately in the laser spot then the sample is scanned laterally to build images."
About JPK Instruments
JPK Instruments AG is a world-leading manufacturer of nanoanalytic instruments - particularly atomic force microscope (AFM) systems and optical tweezers - for a broad range of applications reaching from soft matter physics to nano-optics, from surface chemistry to cell and molecular biology. From its earliest days applying atomic force microscope (AFM) technology, JPK has recognized the opportunities provided by nanotechnology for transforming life sciences and soft matter research. This focus has driven JPK's success in uniting the worlds of nanotechnology tools and life science applications by offering cutting-edge technology and unique applications expertise. Headquartered in Berlin and with direct operations in Dresden, Cambridge (UK), Singapore, Tokyo and Paris (France), JPK maintains a global network of distributors and support centers and provides on the spot applications and service support to an ever-growing community of researchers.
Source: JPK Instruments (press release)
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