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Posted: Mar 04, 2013

Animation clip of nanoparticles for drug delivery in cancer treatment (w/video)

(Nanowerk News) Cancer is a broad group of various diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the body through the lymphatic system or bloodstream. There are over 200 different known cancers that afflict humans.
One out of every four deaths in the United States is from cancer. It is second only to heart disease as a cause of death in the states. About 1.2 million Americans are diagnosed with cancer annually; more than 500,000 die of cancer annually.
Cancer can attack anyone. Since the occurrence of cancer increases as individuals age, most of the cases are seen in adults, middle-aged or older. Sixty percent of all cancers are diagnosed in people who are older than 65 years of age. The most common cancers are skin cancer, lung cancer, colon cancer, breast cancer (in women), and prostate cancer (in men). In addition, cancer of the kidneys, ovaries, uterus, pancreas, bladder, rectum, and blood and lymph node cancer are also included among the 12 major cancers that affect most Americans.
Treatment and prevention of cancers continue to be the focus of a great deal of research. One of cancer treatment is chemotherapy. Is depends on using of drugs to kill cancer cells. It destroys the hard-to-detect cancer cells that have spread and are circulating in the body. Chemotherapeutic drugs can be taken either orally (by mouth) or intravenously, and may be given alone or in conjunction with surgery, radiation or both.
Nanobotmodels Company analyze all scientific progress and clinical tests to make models of nanomedical devices and drug delivery systems. In this animation DNA-origami shell nanoparticle can deliver doxorubicine molecules using specific oncomarkers.
A vision of modern drug delivery methods using DNA-origami nanoparticles. In this animation you can see cancer therapy using doxorubicin, delivered by nanomedicine methods.
Rapid nanotechnology development offer targeted drug delivery. This is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. The goal of a targeted drug delivery system is to prolong, localize, target and have a protected drug interaction only with the diseased tissue. The conventional drug delivery system is the absorption of the drug across a biological membrane, whereas the targeted release system is when the drug is released in a dosage form.
A nanoparticle coated by immune factor, it can prevent attacking nanoparticles by the immune cells. When the nanoparticle conjugate with several specific oncomarkers, it DNA-origami shell opens and doxorubicine flow in the cellís inner space.
Doxorubicin is one of the chemotherapeutic agents and is commonly used to treat some leukemias and Hodgkin's lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma, multiple myeloma, and others.
Incide the cell doxorubicin interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. Doxorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.
In this type of chemotherapy healthy cells stays undamaged. After successfully drug delivery cancer cell dies.
Source: Nanobotmodels
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