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Posted: Jul 22, 2013

Successful control of massive venous bleeding with nanosheets

(Nanowerk News) Severe damage to the large vessels from multiple trauma or accidental complications in surgery can cause exsanguinating hemorrhage leading to death. Especially in the thin-walled vena cava abundant with blood, a tear in a small laceration soon widens, requiring a difficult and specialized vascular surgery technique to be fixed. We developed nano-adhesive plasters that can easily be applied to lacerated vessel walls with no adhesive, and succeeded in arresting massive bleeding from the inferior vena cava in rabbits.
A research group from the National Defense Medical College, in joint research with the Waseda University Graduate School of Advanced Science and Engineering, has developed nano-thickness sheets (1/100000~1/10000 mm) about the same thinness as cell membranes. These pellicle sheets are so-called "nanosheets" that can be perfectly attached, with no gaps, to the organ or tissue surfaces with no adhesive. In a world first, by applying these nanosheets, massive hemorrhaging from thin-walled large vessels such as the vena cava can be arrested. These results recently published in the Journal of Vascular Surgery ("Effective control of massive venous bleeding by 'multi-overlapping therapy' using polysaccharide nanosheets in a rabbit inferior vena cava injury model").
Nanosheets are tightly attached to the surface of any organ and skin with no adhesive, and furthermore, cause no adhesion. Because the nanosheets are transparent, the control of the bleeding can be clearly seen in addition to being able to overlap multiple nanosheets when there is insufficient arrest of the bleeding. A 7 mm incision to a rabbit's inferior vena cava can be fatal, but by applying nanosheets to the bleeding area, we succeeded in quick hemostasis in all the rabbits (wounds to the lungs, digestive tract and the brain's arachnoid membrane can also be simply covered by applying nanosheets).
The scientists hope that nanosheets, which can simply stop bleeding of large vessels without using complicated surgical techniques such as vascular suture, will become considerably useful for effective hemostasis not only in the surgical patients receiving major operations but also in the trauma victims with massive hemorrhage.
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