| Sep 05, 2013 |
Carbon nanotubes functionalized with gold nanowires for hybrid molecular sensing
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(Nanowerk News) Reporting their work in the August 29, 2013 online edition of ACS Nano ("Ultrathin Gold Nanowire-Functionalized Carbon Nanotubes for Hybrid Molecular Sensing"), researchers at the University of Kansas have demonstrated solution-phase synthesized ultrathin gold nanowires incorporated carbon nanotube hybrids as both NIR photoacoustic imaging and efficient electrochemical sensing agents.
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| Noncovalent ultrathin gold nanowires functionalized multiwalled carbon nanotube (GNW-CNT) hybrid sensing agents show highly efficient and selective immune molecular sensing in electrochemical and near-infrared photoacoustic imaging methods. A detection limit of 0.01 ng/mL for the alpha-fetoprotein (AFP) antigen with high selectivity is shown. (©American Chemical Society)
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Noncovalent ultrathin gold nanowire functionalized CNTs preserve the extraordinary optical and thermal properties, and more importantly, exhibit high water solubility and further biological molecule functionalization. The presented hybrid golden carbon nanotubes own high optical absorption, thermal and electric conductivity.
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The research team showed the high selectivity and sensing efficiency of hybrid GNW-CNTs by conjugating with targeted molecules. In addition, the morphology change under laser exposure and high thermal conductivity of CNTs also facilitates the disconnection process of GNWs, which could open up potential applications by releasing the drug conjugated on the GNWs into the targeted area under the laser illumination at certain intensity.
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Moreover, they showed that GNW-CNT conjugated with anti-AFP antigen has the ability to specifically link to the AFP antigen, and demonstrated a detection limit of 0.01 ng/mL for the AFP antigen with high selectivity, as one model detection system.
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