A wide range of biological and biodegradable materials have been electrospun in recent years to produce nanofibers. In this research, a drug carrying nanofibrous web was produced to be used in wound dressing by using an artificial and biodegradable polymer and a natural polymer through electrospinning method.
Honey has antibacterial and anti-inflammation properties. Many studies have been published on the effects of honey in the treatment of infections and in prevention of the wound from being infected. Therefore, the combination of the unique properties of nanofibers and the natural properties of honey in the production of wound dressing is the most important characteristic of this research.
SEM and AFM results showed that the fibers were completely homogenous with relatively smooth surface. However, spindle-like beads were observed in nanofibers containing 60% honey. As the concentration of honey increased in the mixture, a decrease was observed in the diameter of nanofibers. Drug-loaded nanofibers, too, had relatively smooth and homogenous surface, and as the amount of drug increases, the diameter of the nanofibers decreased. Drug release behavior studies demonstrated a sudden initial release. Statistical analyses showed that the presence of honey did not have significant effect on the process or on the behavior of drug release. Therefore, electrospun nanofibers that contain honey are appropriate option to be used in wound dressing.
Wounds can be dressed faster by using the achievements of this research. Honey is considered as a well-known drug in traditional medical sciences, which has been loaded with drugs in this research.