Researchers have demonstrated that a small molecule can transport iron in human cells and live animals when proteins that normally do the same job are missing, a condition that often causes severe anemia in patients.
Through 'heart-on-a-chip' technology - modeling a human heart on an engineered chip and measuring the effects of compound exposure using microelectrodes - researchers hope to ensure potentially lifesaving new drugs are safe and effective while reducing the need for human and animal testing.
Researchers hope that the stem cells will possibly form new disc cartilage once injected into a damaged disc. A new study on three sick German shepherds demonstrates that a treatment with the body's own stem cells are well tolerated - an important first step.
Scientists present in atomic detail how specific bacterial enzymes, known as kinases, confer resistance to macrolide antibiotics, a widely used class of antibiotics and an alternative medication for patients with penicillin allergies. The study shows for the first time how these kinases recognize and chemically destroy macrolide antibiotics.