A Stanford University School of Medicine team led by Cathy Shachaf, Ph.D., has for the first time used specially designed dye-containing nanoparticles to simultaneously image two features within single cells. Although current single-cell flow cytometry technologies can provide up to 17 simultaneous visualizations, this new method has the potential to do far more.
Researchers have created tools for the early diagnosis of pancreatic cancer by attaching a molecule that binds specifically to pancreatic cancer cells to iron oxide nanoparticles that are clearly visible under magnetic resonance imaging (MRI).
Gold nanoshells are among the most promising new nanoscale therapeutics being developed to kill tumors, acting as antennas that turn light energy into heat that cooks cancer to death. Now, a multi-institutional research team has shown that polymer-coated gold nanorods one-up their spherical counterparts, with a single dose completely destroying all tumors in a nonhuman animal model of human cancer.
Two new construction manuals are now available for the world's smallest lamps. Based on these protocols, scientists from the Max Planck Institute of Colloids and Interfaces have tailor-made nanoparticles that can be used as position lights on cell proteins and, possibly in the future as well, as light sources for display screens or for optical information technology.
In the bustling economy of the cell, little bubbles called vesicles serve as container ships, ferrying cargo to and from the port - the cell membrane. Some of these vesicles, called post-Golgi vesicles, export cargo made by the cell's protein factory. Scientists have long believed that other, similar vesicles handle the reverse function, importing life-supporting nutrients and proteins through an independent process. By using a finely honed type of microscopy to more precisely examine these transactions, new research shows the processes are not as independent as assumed: certain molecules handle cargo moving in both directions.
Wissenschaftler vom Institut für Biomedizinische Technik der ETH Zürich haben eine Nanospritze entwickelt, mit welcher Medikamente, DNA und RNA in eine einzelne Zelle injiziert werden können, ohne diese zu verletzen.
EPA is promulgating further significant new use rules (SNUR) under section 5(a)(2) of the Toxic Substances Control Act (TSCA) for 23 chemical substances which were the subject of premanufacture notices.
Berkeley Lab scientists stunned the world in 2006 when they proved they could accelerate electrons to very high energies (1 GeV, or a billion electron volts) in a distance of centimeters rather than hundreds of meters. Using the same concepts, those scientists plan to take the project to the next level and build a laser-based accelerator capable of zapping electron beams to energies exceeding 10 GeV in a distance of just one meter.
Ken Matsuoka and co-workers at the RIKEN Plant Science Center in Yokohama, Kyushu University in Fukuoka and Niigata University have discovered a subcellular structure in plants that carries proteins and glycans to the correct locations, especially outside of the cell.
An international team, led by Shingo Nagano from the RIKEN SPring-8 Center in Harima and Hiroyasu Onaka from Toyama Prefectural University, has uncovered the vital role of water in the generation of the antitumor drug staurosporine.
In a landmark technical achievement, investigators in the Vanderbilt Center for Structural Biology have used nuclear magnetic resonance (NMR) methods to determine the structure of the largest membrane-spanning protein to date.