Showing Spotlights 713 - 720 of 2204 in category All (newest first):
Assessing the potential effects of nanomaterials on environment and human health consists of two distinct aspects: To what degree are nanoparticles released from products; and how and to what degree do the released nanoparticles affect organisms? The first aspect is centered on a field called exposure science, the study of human contact to agents - such as chemicals or microbes - found in their surroundings. A new study looks at the release of nanosilver from consumer products for children. The core finding is that the release of silver from nanosilver-containing products depends heavily on how the product is used. The total amount of silver released by a consumer product is likely to be very low and, for the products tested, happened only in the beginning of product life.
Jul 30th, 2013
Researchers report on a novel targeted drug-delivery vehicle for cancer therapy, which can selectively target the tumor niche while delivering an array of therapeutic agents. This targeting platform is based on unique vesicles ('nanoghosts') that are produced, for the first time, from intact cell membranes of stem cells with inherent homing abilities, and which may be loaded with different therapeutics. The team showed that such vesicles, encompassing the cell surface molecules and preserving the targeting mechanism of the cells from which they were made, can outperform conventional delivery systems based on liposomes or nanoparticles.
Jul 26th, 2013
Surface Enhanced Raman Spectroscopy (SERS) is a powerful analytical method that can detect trace amounts of substances, such as narcotics, toxins, and explosives. The detection is based on the fact that molecules of different substances interacting with light from a laser will scatter the light differently, providing a unique spectrum that can be used to identify the substance, much like a fingerprint. Researchers have used a microfluidic device to orchestrate the interactions between silver nanoparticles and methamphetamine molecules in saliva. The microfluidic device allows for the controlled introduction of the sample and the nanoparticles, and the subsequent aggregation of the nanoparticles into hot-spot rich clusters that allow us to detect minute amounts of the drug.
Jul 25th, 2013
Understanding the purpose of the molecular modifiers that annotate DNA strands - called epigenetic markers - and how they change over time will be crucial in understanding biological processes ranging from embryo development to aging and disease. But just how the markers work, and what different markers mean, is painstaking work that still has left a long way to go. Advancing this research field, scientists have now reported the first direct visualization of individual epigenetic modifications in the genome. This is a technical and conceptual breakthrough as it allows not only to quantify the amount of modified bases but also to pin point and map their position in the genome.
Jul 24th, 2013
When nanoparticles enter the human body, for instance as part of a nanomedicine application, they come into immediate contact with a collection of biomolecules, such as proteins, that are characteristic of that environment, e.g. blood. A protein may become associated with the nanomaterial surface during a protein-nanomaterial interaction, in a process called adsorption. The layers of proteins adsorbed to the surface of a nanomaterial at any given time is known as the protein corona. The type and amount of proteins in the corona composition is strongly dependent on several factors, including physicochemical properties of nanoparticles; protein source; and protein concentration - and temperature.
Jul 23rd, 2013
Direct visualization and manipulation of individual carbon nanotubes (CNTs) in ambient conditions is of great significance for their characterizations and applications. However, the direct visualization, location, and manipulation of individual CNTs is extremely difficult due to their nanoscale diameters. The observation of individual CNTs usually requires electron microscopes under high vacuum. Researchers now have proposed a facile way to realize optical visualization of individual carbon nanotubes and, based on that, macroscale manipulation of individual carbon nanotubes that could be carried out under an optical microscope.
Jul 22nd, 2013
Electronics will undergo revolutionary changes as the relatively novel disciplines of spintronics, nanoelectronics, and quantum computing come of age. A fundamental link between these fields can be established using molecular magnetic materials and, in particular, single-molecule magnets. Researchers have now demonstrated how to noninvasively graft a single-molecule magnet onto a carbon nanotube nanoelectromechanical system and probe the molecular nanomagnet with the carbon nanotube's mechanical motion.
Jul 19th, 2013
The study of individual cells is of great importance in biomedicine. Many biological processes incur inside cells and these processes can differ from cell to cell. The development of micro- and nanoscale tools smaller than cells will help in understanding the cellular machinery at the single cell level. All kinds of mechanical, biochemical, electrochemical and thermal processes could be studied using these devices. Researchers have now demonstrated a nanomechanical chip that can be internalized to detect intracellular pressure changes within living cells, enabling an interrogation method based on confocal laser scanning microscopy.
Jul 18th, 2013