| Posted: Jan 26, 2018 |
Graphene oxide is 'sensed' by specialised cells of the immune system
(Nanowerk News) A study by researchers at Karolinska Institutet, the University of Manchester and Chalmers University of Technology published in CHEM ("Graphene Oxide Elicits Membrane Lipid Changes and Neutrophil Extracellular Trap Formation") shows that our immune system handles graphene oxide in a manner similar to pathogens, paving the way for safer biomedical applications of this two-dimensional material.
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Graphene is the thinnest material known to man, a million times thinner than a human hair. Graphene oxide (GO), in turn, is an atomically thin material consisting only of carbon and oxygen atoms. GO is currently being considered for numerous uses including drug delivery and other medical applications. However, it is of critical importance to understand how these materials interact with the body.
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In a new study led by Professor Bengt Fadeel at the Institute of Environmental Medicine, Karolinska Institutet, it is shown that neutrophils, the most common type of white blood cell that is specialised in combating infections, release so-called neutrophil extracellular traps (NETs) when encountering GO. NETs are made up of a “spider-web” of DNA decorated with proteins that help neutrophils to destroy microorganisms such as bacteria and fungi.
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The researchers found that GO causes specific changes in the lipid composition of the cell membrane of neutrophils leading to the release of NETs. They could also show that antioxidant treatment reversed this process. In a companion study published in Nanoscale, it was shown that GO is degraded in NETs, much like bacteria and other pathogens.
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“Taken together, these studies show that GO can be trapped and degraded in NETs just like pathogens. Understanding how the immune system senses and handles GO paves the way for safer biomedical applications of GO and other graphene-based materials, for instance in the context of drug delivery”, says Professor Bengt Fadeel.
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The current study, performed at Karolinska Institutet in collaboration with Professor Kostas Kostarelos at the National Graphene Institute, University of Manchester, and the National Center of Imaging Mass Spectrometry at Chalmers University of Technology. The Graphene Flagship Project has over 150 academic and industrial partners and a total budget of €1 billion. The objectives are to develop new technologies and applications by exploiting the unique properties of graphene and other 2-D materials. The project is coordinated by Chalmers University of Technology.
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