Posted: May 5, 2010

Particle Technology Labs Adds Malvern's Morphologi G3 to its Testing Technologies

(Nanowerk News) Particle Technology Labs (Chicago, USA) has added the Morphologi G3 from Malvern Instruments to the extensive range of technologies it has available for analyzing its clients’ materials. PTL, which is based in Chicago, is a leading service laboratory dedicated to quality particle sizing and characterization. Operating under cGMP, PTL is also FDA registered, DEA licensed and holds an ATF permit. The Morphologi G3 fully automated microscope based image analysis system delivers information on particle shape as well as size. Having used manual microscopy techniques for some time, automation was a high priority for the PTL team, and influential in their decision to purchase the system.
Bill Kopesky, PTL’s VP of Analytical Services, confirms the growing need to understand the importance and effects of particle shape. “We have often supplemented laser diffraction particle size distribution data and other techniques which assume equivalent spherical diameters, for example, with microscopic examination and the acquisition of representative images of the particles,” he said. “Increasingly now our clients want to know even more about their materials, to be able to elucidate process differences perhaps, or for finer discrimination between two samples.”
The Morphologi G3 in use at PTL
The Morphologi G3 in use at PTL.
“Not only has the Morphologi G3 allowed us to move away from manual imaging methods, we can now process large numbers of images in many different ways and examine a wide variety of parameters to provide more detailed information and the extra insight required. And, it has quickly become our instrument of choice for characterizing elongated and non-spherical particles where applications allow.”
Currently PTL uses the Morphologi G3 primarily for method development and troubleshooting, and mostly for dry powders, for which the system has an integral dispersion unit:
“We have been impressed with the capabilities of the automated dispersion system,” said Mr Kopesky. “Also the wide particle size range that can be measured using multiple objectives means that we do not need to prepare multiple samples. This combination of speed, automation and walkaway capability helps us maximize throughput and make best use of operator time.”
PTL also has liquid dispersion capabilities with the instrument by using a wet cell accessory. In addition, they have been able to assist clients in the filtration industry by collecting dilute particle suspensions onto filters and using episcopic illumination to measure the collected particulate using the Morphologi G3.
About the Morphologi G3
The Morphologi G3 measures particles from 0.5 to 10000 µm, capturing microscope quality images. Software tools, including an interactive scattergram, make it easy to visualise, classify and filter the results, for statistical interrogation of the data. It is driven by Standard Operating Procedures (SOPs) with single click operation from dispersion through to results. Automatic calibration, conformance to 21 CFR part 11 requirements and the availability of full IQ/OQ documentation, ensure that the system operates repeatably and that all data is secure and validated.
About Malvern Instruments
Malvern Instruments is a market leader in measuring performance controlling material properties. These include particle size, particle shape, zeta potential, molecular weight, size and conformation, rheological properties and chemical distribution. Malvern delivers the systems, support and expertise that ensure the analytical rigor and productivity needed to drive research, development and manufacturing.
Malvern’s measurement solutions for scientists, technologists and engineers advance continually through customer collaboration. Complementary materials characterization systems deliver inter-related measurements that reflect the complexities of particulates and disperse systems, nanomaterials and macromolecules. Combining intelligently implemented technologies with in-depth industry applications knowledge and support, Malvern provides customers with the competitive advantage they demand.
Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Korea and Japan, a joint venture in India, a global distributor network and applications laboratories around the world.
About PTL
Particle Technology Labs was founded in 1992 by Richard F. Karuhn as an independent laboratory. Since then, it has grown to be the leading independent service laboratory for particle characterization in the United States. PTL offers analytical solutions to many of the top pharmaceutical, environmental, food, health, beauty and industrial companies worldwide.
PTL utilizes a variety of instruments from leading major manufacturers, keeping both on the cutting edge of particle technology, and staying familiar with the time-tested and classical methodologies. As a conscientious service lab PTL makes certain that samples are analyzed by the most appropriate method and not forced to "fit" onto one specific manufacturer's instrument.
Particle Technology Labs analytical team has extensive experience in the science of fine particle characterization. Their team is available to assist throughout the entire project – from initial consultation to data interpretation upon completion. PTL can aid in choosing the optimal procedure and instrumentation for your sample type as well as provide innovative solutions for specific needs.
Source: Malvern Instruments (press release)
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