Access Pharmaceuticals Cobraxane Program Displays Significant Advantage Over Commercially-Available Paclitaxel Protein-Bound Particles

(Nanowerk News) Access Pharmaceuticals, a biopharmaceutical company leveraging its proprietary drug-delivery platforms to develop treatments in areas of oncology, cancer supportive care and diabetes, announced that it has made significant progress with its CobaCyte™ tumor-targeting technology. Using a new proprietary CobaCyte paclitaxel nanoparticle formulation, named Cobraxane™, the company's scientists have observed significant tumor growth inhibition in preclinical tumor models.
In a murine solid tumor models, single doses of Cobraxane were compared with single doses of commercially-available paclitaxel protein-bound particles (AbraxaneŽ). At a dose of Cobraxane which was half that of the maximum tolerated dose (MTD) of the standard paclitaxel particles, Cobraxane demonstrated slightly better tumor growth inhibition than the MTD dose of standard paclitaxel particles. Cobraxane, injected at the same dose at the MTD dose of standard paclitaxel particles, provided significantly better tumor growth inhibition than the MTD dose of standard paclitaxel particles. In fact, at the higher dose of Cobraxane, tumor shrinkage was observed.
"We know that in certain diseases, notably cancer, the affected cells can have an elevated demand for certain vitamins, including vitamin B12, and this principle serves as the scientific basis of our CobaCyte tumor-targeting technology," said David Nowotnik, Senior Vice President Research and Development, Access Pharmaceuticals, Inc. He continued, "The preclinical work done by the Access scientific team is key in evaluating and defining the potential efficacy and specificity of Cobraxane in a variety of different tumors and we are pleased with our early findings."
Jeffrey Davis, CEO of Access Pharmaceuticals stated, "The data observed in our Cobraxane models serves as a strong indicator of the potential clinical and commercial value Cobraxane offers. Given the recent activity in the market surrounding the therapeutic impact associated with paclitaxel protein-bound chemotherapy, we are excited about the comparative data seen in our preclinical models and look forward to furthering the development of the Cobraxane program."
Abraxane is a registered trademark of Celgene Corporation.
About Access
Access Pharmaceuticals, Inc. is an emerging biopharmaceutical company that develops and commercializes proprietary products for the treatment and supportive care of cancer patients. Access' products include MuGard™ (, which has received FDA marketing clearance for the management of patients with mucositis, ProLindac™, a second generation DACH Platinum in Phase 2 clinical testing of patients with ovarian cancer, and Thiarabine™, a novel nucleoside analog that has demonstrated both pre-clinical and clinical activity in certain cancers; currently in a Phase 1/2a trial in hematological malignancies at M.D. Anderson Cancer Center in Houston, Texas.
The company also has other advanced drug delivery technologies including CobaCyte™-mediated targeted delivery and CobOral-oral drug delivery, its proprietary nanopolymer delivery technology based on the natural vitamin B12 uptake mechanism. For additional information on Access Pharmaceuticals, please visit our website at
Source: Access Pharmaceuticals (press release)
Subscribe to a free copy of one of our daily
Nanowerk Newsletter Email Digests
with a compilation of all of the day's news.
These articles might interest you as well: