The latest news from academia, regulators
research labs and other things of interest
Posted: Feb 07, 2012
NanoInk Launches Contract Services Program for Live Single Cell Assay Work
(Nanowerk News) NanoInk's® NanoFabrication Systems Division announced today
that it introduced a new contract services program dedicated to the development of live single cell array
assays. This offering supplements NanoInk's portfolio of Dip Pen Nanolithography® (DPN®)-based
systems and tools used for micro and nanopatterning applications to include a service component. Life
scientists now have even more ways to access the advantages of DPN for their research.
At the heart of the NanoFabrication Systems' contract services program is its DPN nanofabrication
instruments capable of constructing complex multiplexed patterns of biocompatible materials at subcellular
scales. This capability can be utilized to construct defined microenvironments for attaching live
single cells and subsequently investigating cellular responses. Single cells (up to 5,000 individual cells on
a single NanoInk chip) can be exposed to different external stimuli (including biological, chemical and
topographical stimuli) and the downstream effects of these stimuli can be monitored at the cellular,
proteomic or genomic levels. Additionally, studies on limited or rare cells harvested from a patient can
potentially be exposed to many conditions, making theranostic applications possible. This new contract
services program will enable researchers to engage NanoInk to design, develop and construct custom
single cell assays.
"We believe that NanoInk's single cell assay technology has the potential to revolutionize in vitro cell
biology research, including applications in drug toxicity testing and drug screening. Micropatterned
single cells can also be harnessed to probe underlying mechanisms of cell behavior like cell-cell
interactions, cell-surface interactions, cell migration, and cell invasion," explained Tom Warwick,
general manager of the NanoFabrication Systems Division.
NanoInk has already demonstrated the ability of its nanofabrication platform to place single cells at
defined locations on a substrate and to then expose individual cells to small molecules and nanoparticles.
Saju Nettikadan, Ph.D., director of applications development at NanoInk, said, "NanoInk findings also
show that two different cell types can be placed at defined locations on a single chip to form single cell
co-cultures. We have demonstrated the single cell co-culture proof-of-concept using 3T3 fibroblasts
and C2C12 myoblasts. As part of our live single cell assay contract research program, we welcome
requests to design and develop custom assays."
NanoInk's NanoFabrication Systems Division brings sophisticated nanofabrication to the laboratory
desktop in an easy to use and affordable setting. For more information on nanofabrication instruments
and tools, as well as the new single cell assay contract services program, please contact Tom Warwick at
[email protected], (847)679-NANO (6266) or visit www.nanoink.net/divisions.html#NanoFabrication.
NanoInk, Inc. is an emerging growth technology company specializing in nanometer-scale
manufacturing and applications development for the life sciences, engineering, pharmaceutical, and
education industries. Using Dip Pen Nanolithography® (DPN®), a patented and proprietary
nanofabrication technology, scientists are enabled to rapidly and easily create micro-and nanoscale
structures from a variety of materials on a range of substrates. This low cost, easy to use and scalable
technique brings sophisticated nanofabrication to the laboratory desktop. Headquartered in the Illinois
Science + Technology Park, north of Chicago, NanoInk currently has several divisions including the
NanoFabrication Systems Division, the Nano BioDiscovery Division, the NanoProfessor™ Division and
the NanoGuardian™ Division. For more information on products and services offered by NanoInk, Inc.,