Posted: July 16, 2008

JPK Announces CellHesion200, the Single Cell Force Testing Solution for the Study of Cellular Elasticity and Adhesion

(Nanowerk News) The measurement of cell adhesion and cell elasticity is a primary focus of research activity in the life sciences. Many different disciplines are interested in the interaction of cells with other cells or substrates. This is especially true for biophysics, biochemistry, cellular and medical research in cell migration, implant research, wound healing, developmental biology, stem cell research, infection biology and immune response.
To date, cellular adhesion has been studied with fluorescence microscopy, capillary techniques or mechanical methods such as rotation assays and flow chambers. All these methods have their limitations. Either they provide qualitative, difficult-to-interpret results or are difficult to operate. The need for quantitative and statistically reliable measurements has proven elusive – until now. With the new CellHesion®200, JPK Instruments has created an integrated system for measuring cell-cell and cell-substrate interactions.
The CellHesion®200 may be integrated with a standard optical inverted microscope in less than a minute to provide the user flexibility and expanding the spectrum of possible control experiments.
CellHesion® technology provides quantitative and reliably reproducible measurements of the adhesive and stiffness characteristics of living cells. The system delivers precise information about single molecule behavior. Additionally, quantifiable and reproducible data can be produced for a number of important parameters involved in cell adhesion, including single bond partner interactions. CellHesion®200 can also be used to determine mechanical characteristics such as cell elasticity or stiffness.
About JPK Instruments
JPK Instruments AG is one of the world’s leading manufacturer of nanoanalytic instruments - particularly atomic force microscope (AFM) systems and optical tweezers- for research in life sciences and soft matter.
JPK was recognized as Germany’s fastest growing nanotechnology company in 2007 (Deloitte) and this was demonstrated by the foresight to purchase companies such as lpi and nAmbition enabling rapid time to market for new products such as optical tweezers and automated force spectroscopy systems. From its earliest days applying atomic force microscope (AFM) systems, JPK has recognized the opportunities provided by nanotechnology for application from biophysical to biomedical research, tailoring its instrument platforms to meet user requirements.
Headquartered in Berlin and with operations in Dresden and Cambridge (UK), JPK maintains a global network of distributors and support centers and provides on the spot applications and service support to an ever-growing community of researchers.
Source: JPK Instruments
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