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Posted: Dec 21, 2017
Molecular mapping made easy
(Nanowerk News) Every day, every inch of skin on your body comes into contact with thousands of molecules -- from food, cosmetics, sweat, the microbes that call your skin home. Now researchers can create interactive 3D maps that show where each molecule lingers on your body, thanks to a new method developed by University of California San Diego and European Molecular Biology Laboratory (EMBL) researchers. The technique is published in Nature Protocols ("3D molecular cartography using LC–MS facilitated by Optimus and 'ili software").
3-D map of the molecules on an ATM machine. This map demonstrates how we transfer molecules from our skin to the objects we interact with, providing information that may have many forensic applications. (Image: UC San Diego and EMBL)
The goal of this 3D mapping is to better understand how molecules from our surroundings, as well those produced by our bodies and the microbial communities on our skin, influence one another and our health.
When the team previously used this approach to map the molecules on the skin of two volunteers, they found prevalent traces of sunscreen and other hygiene products, even three days after they'd last been used.
3-D map of the molecules on a rosemary spring. The old leaves at the bottom of the rosemary plant have much higher levels of the flavonoid cirsimaretin than the newer leaves at the top. Using maps like this, scientists can study how plants transport molecules from old leaves to young ones, or how they react to stress. (Image: UC San Diego and EMBL)
The 3D molecular mapping method is the brainchild of Pieter Dorrestein, PhD, professor in UC San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences, Theodore Alexandrov, PhD, team leader at EMBL in Germany, and their teams. They determined how best to collect the samples, determine their chemical composition using mass spectrometry, and build the mapping software used for analysis.
After they were approached by many colleagues from fields as diverse as forensics, cosmetics, ecology and agriculture, the researchers converted the 3D molecular mapping method into a step-by-step recipe with intuitive software and made it available to the global scientific community.